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Article
Open AccessGenome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal le...
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Article
Open AccessThe wide variety of reasons for feeling guilty in adults: findings from a large cross-sectional web-based survey
Experiencing some sort of guilt is a common phenomenon in adulthood. As feeling guilty is usually unpleasant and may even lead to further negative psychological consequences like depression, the aim of this st...
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Article
Correlates of hospitalization among the oldest old: results of the AgeCoDe–AgeQualiDe prospective cohort study
Hospitalization is a key driver of health care costs. Thus far, there are only a few longitudinal studies investigating whether changes in explanatory variables lead to hospitalization. Moreover, these longitu...
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Article
Open AccessAlzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
Late-onset Alzheimer’s disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present st...
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Article
Open AccessAgeWell.de – study protocol of a pragmatic multi-center cluster-randomized controlled prevention trial against cognitive decline in older primary care patients
In the absence of treatment options, the WHO emphasizes the identification of effective prevention strategies as a key element to counteract the dementia epidemic. Regarding the complex nature of dementia, tri...
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Article
Open AccessTestosterone imbalance may link depression and increased body weight in premenopausal women
Accumulating evidence supports a link between depression and being overweight in women. Given previously reported sex differences in fat accumulation and depression prevalence, as well as the likely role of se...
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Article
Open AccessOlfactory function is associated with cognitive performance: results from the population-based LIFE-Adult-Study
Studies in older adults or those with cognitive impairment have shown associations between cognitive and olfactory performance, but there are few population-based studies especially in younger adults. We there...
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Article
Open AccessAuthor Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML ...
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Article
Olfactory dysfunction: properties of the Sniffin’ Sticks Screening 12 test and associations with quality of life
The Sniffin’ Sticks Screening 12 test is a test of olfactory performance based on pen-like odor dispensing devices. The aims of this study were to analyze the performance of this test in a general population s...
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Article
Open AccessInformal caregivers’ perspectives on health of and (potentially inappropriate) medication for (relatively) independent oldest-old people – a qualitative interview study
Oldest-old persons frequently receive potentially inappropriate medication. Medication use takes place under the patients’ informal caregivers’ influence. We explored informal caregivers’ perspectives on medic...
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Article
Open AccessPrevalence of pain and its associated factors among the oldest-olds in different care settings – results of the AgeQualiDe study
The prevalence of pain is very common in the oldest age group. Managing pain successfully is a key topic in primary care, especially within the ageing population. Different care settings might have an impact o...
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Article
Open AccessStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and...
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Article
Open AccessMemory-related subjective cognitive symptoms in the adult population: prevalence and associated factors – results of the LIFE-Adult-Study
Subjectively perceived memory problems (memory-related Subjective Cognitive Symptoms/SCS) can be an indicator of a pre-prodromal or prodromal stage of a neurodegenerative disease such as Alzheimer’s disease. W...
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Article
Open AccessThe impact of social engagement on health-related quality of life and depressive symptoms in old age - evidence from a multicenter prospective cohort study in Germany
Thus far, only a few longitudinal studies investigated the impact of social engagement on health-related quality of life (HRQoL) and depressive symptoms in old age. Therefore, we aimed to examine the impact of...
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Article
Dementia Recognition and Cognitive Performance in Relation to Elderly Patients’ Social Integration
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Dementia Recognition and Cognitive Performance in Relation to Elderly Patients’ Social Integration
A German study on dementia (Ageing, Cognition and Dementia in Primary Care Patients, Age- CoDe) found that family practitioners (FPs) identify mild dementia less frequently in patients without a partner. The r...
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Article
Open AccessAdvance directives and power of attorney for health care in the oldest-old – results of the AgeQualiDe study
Completion of advance directives (ADs) and power of attorney (POA) documents may protect a person’s autonomy in future health care situations when the individual lacks decisional capacity. As such situations b...
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Article
Open AccessGeneral practitioners’ views on (long-term) prescription and use of problematic and potentially inappropriate medication for oldest-old patients—A qualitative interview study with GPs (CIM-TRIAD study)
Potentially inappropriate medication (PIM) is defined as medication with uncertain therapeutic effects and/or potential adverse drug reactions outweighing the clinical benefits. The prescription rate of PIM fo...
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Article
Open AccessOutcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+)
Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all ...
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Article
Gender differences in the effect of social support on health-related quality of life: results of a population-based prospective cohort study in old age in Germany
The causality between social predictors and HRQoL in old age remains almost unclear as only a few studies have examined the influence of social support on HRQoL in a longitudinal setting. Moreover, available ...
