28 Result(s)
within
Matthias L. Schroeter
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Article
Open AccessTau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies
We hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe striatal dopamine deficiency in four-repeat (4R) tauopathies. The...
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Open AccessThe Behavioural Dysfunction Questionnaire discriminates behavioural variant frontotemporal dementia from Alzheimer’s disease dementia and major depressive disorder
Early-stage behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed, highlighting the need for new diagnostic instruments. Based on the revised diagnostic criteria for bvFTD, we developed the...
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Open AccessHeart failure decouples the precuneus in interaction with social cognition and executive functions
Aging increases the risk to develop Alzheimer’s disease. Cardiovascular diseases might accelerate this process. Our study aimed at investigating the impact of heart failure on brain connectivity using function...
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Open AccessAdditive value of [18F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome
Early after [18F]PI-2620 PET tracer administration, perfusion imaging has potential for regional assessment of neuronal injury in neurodegenerative diseases. This is while standard late-phase [18F]PI-2620 tau-PET...
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Open AccessSocial determinants and lifestyle factors for brain health: implications for risk reduction of cognitive decline and dementia
Substantial evidence indicates a huge potential for risk reduction of cognitive decline and dementia based on modifiable health and lifestyle factors. To maximize the chances for risk reduction, it is useful t...
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Open AccessComparative analysis of machine learning algorithms for multi-syndrome classification of neurodegenerative syndromes
The entry of artificial intelligence into medicine is pending. Several methods have been used for the predictions of structured neuroimaging data, yet nobody compared them in this context.
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Open AccessTau deposition patterns are associated with functional connectivity in primary tauopathies
Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected n...
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Open AccessFeasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy
Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [18F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy con...
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Open AccessMolecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 cases
Approximately 30% of individuals with severe SARS-CoV-2 infections also develop neurological and psychiatric complaints. In rare cases, the occurrence of autoimmune encephalitis has been reported after SARS-Co...
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Open AccessClinico-genetic findings in 509 frontotemporal dementia patients
Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic ...
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Open AccessEarly-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers...
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Open AccessAre social conflicts at work associated with depressive symptomatology? Results from the population-based LIFE-Adult-Study
Psychosocial stressors in the workplace can be detrimental to mental health. Conflicts at work, e.g. aggression, hostility or threats from coworkers, supervisors or customers, can be considered a psychosocial ...
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Article
Genetic architecture of subcortical brain structures in 38,851 individuals
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate n...
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Open AccessModulatory Effects of Levodopa on Cerebellar Connectivity in Parkinson’s Disease
Levodopa has been the mainstay of symptomatic therapy for Parkinson’s disease (PD) for the last five decades. However, it is associated with the development of motor fluctuations and dyskinesia, in particular ...
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Article
The applause sign in frontotemporal lobar degeneration and related conditions
The applause sign, i.e., the inability to execute the same amount of claps as performed by the examiner, was originally reported as a sign specific for progressive supranuclear palsy (PSP). Recent research, ho...
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Open AccessBenefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibition
Clinical benefits of pallidal deep brain stimulation (GPi DBS) in dystonia increase relatively slowly suggesting slow plastic processes in the motor network. Twenty-two patients with dystonia of various distri...
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Open AccessUnraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson’s disease patients
The effects of dopaminergic therapy for Parkinson’s disease (PD) on the brain functional architecture are still unclear. We investigated this topic in 31 PD patients (disease duration: 11.2 ± (SD) 3.6 years) w...
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Psychometric properties of the Satisfaction with Life Scale (SWLS), derived from a large German community sample
The aim of this study was to test psychometric properties of the Satisfaction with Life Scale (SWLS), to provide normative values, and to analyze associations between life satisfaction and sociodemographic and...
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Open AccessMemory-related subjective cognitive symptoms in the adult population: prevalence and associated factors – results of the LIFE-Adult-Study
Subjectively perceived memory problems (memory-related Subjective Cognitive Symptoms/SCS) can be an indicator of a pre-prodromal or prodromal stage of a neurodegenerative disease such as Alzheimer’s disease. W...
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Open AccessA language-based sum score for the course and therapeutic intervention in primary progressive aphasia
With upcoming therapeutic interventions for patients with primary progressive aphasia (PPA), instruments for the follow-up of patients are needed to describe disease progression and to evaluate potential thera...
