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Article
Open AccessFrom methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions
In the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have previously shown that D...
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Article
Open AccessMachine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease
Cognitive impairment is a debilitating symptom in Parkinson’s disease (PD). We aimed to establish an accurate multivariate machine learning (ML) model to predict cognitive outcome in newly diagnosed PD cases f...
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Article
Open AccessDNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. We profiled DNA methylation in...
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Chapter
Epigenome-Wide Association Studies in Psychiatry: Achievements and Problems
Genetic variation can only explain a small portion of risk to psychiatric disorders, including major depressive disorder, schizophrenia, and post-traumatic stress disorder. Epidemiological studies are increasi...
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Article
Open AccessNovel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons
Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they captu...
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Article
Open AccessA meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex
Epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, although existing studies have been limited in sample size and utilized differe...
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Article
Open AccessMeta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm...
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Chapter
Epigenetics in Drug Discovery: Achievements and Challenges
The epigenome comprises a range of covalent modifications of DNA and histone proteins that establish chromatin structure and function. These processes regulate gene expression without altering the DNA sequence...
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Article
Open AccessLongitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder
Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to ...
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Article
Open AccessAlzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
Late-onset Alzheimer’s disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present st...
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Article
Open AccessParallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease
Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distingu...
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Article
A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex
We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer’s disease (AD) cases and matched controls using chromatin immunoprecipitation and highly par...
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Article
Open AccessNewborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1
There is increasing evidence for the role of prenatal stress in sha** offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregn...
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Article
The epigenome and postnatal environmental influences in psychotic disorders
Schizophrenia spectrum disorders and bipolar spectrum disorders are the product of both heritable and non-heritable factors, the impact of which converges at different biological levels. Recent evidence from m...
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Article
Epigenetic epidemiology in psychiatry: A translational neuroscience perspective
Accumulating evidence from the field of neuroscience indicates a crucial role for epigenetic regulation of gene expression in development and aging of nervous system and suggests that aberrations in the epigen...
