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Article
The impact of low-fat and full-fat dairy foods on symptoms of gastroesophageal reflux disease: an exploratory analysis based on a randomized controlled trial
Gastroesophageal reflux disease (GERD) is a widely prevalent condition. High consumption of dairy foods and dietary fat are associated with worse GERD symptoms. However, existing data are inconsistent and most...
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Article
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival
Tissue miRNA can discriminate between esophageal adenocarcinoma (EA) and normal epithelium. However, no studies have examined a comprehensive panel of circulating miRNAs in relation to EA diagnosis and survival.
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Article
Open AccessAlcohol drinking and head and neck cancer risk: the joint effect of intensity and duration
Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.
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Article
Open AccessInteractive decision support for esophageal adenocarcinoma screening and surveillance
A key barrier to controlling esophageal adenocarcinoma (EAC) is identifying those most likely to benefit from screening and surveillance. We aimed to develop an online educational tool, termed IC-RISC™, for pr...
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Article
Open AccessCorrection to: NSAID use and somatic exomic mutations in Barrett’s esophagus
It was highlighted that in the original article [1] the Availability of data and materials section was incorrect.
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Article
Open AccessWhole-genome sequencing of esophageal adenocarcinoma in Chinese patients reveals distinct mutational signatures and genomic alterations
While the incidence of esophageal adenocarcinoma (EAC) has risen drastically in Western countries over the last 40 years, a similar trend has not been observed for EAC in China. Here, we analyzed mutational sp...
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Article
Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium
There have been few published studies on differences between Blacks and Whites in the estimated effects of alcohol and tobacco use on the incidence of head and neck cancer (HNC) in the United States. Previous ...
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Article
Open AccessNSAID use and somatic exomic mutations in Barrett’s esophagus
Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the metaplastic condition Barrett’s esophagus (...
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Article
Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma
Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its prec...
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Article
Open AccessEvidence against a role for jaagsiekte sheep retrovirus in human lung cancer
Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols produced by infected animals. Virus entry into cells is initiated by binding of the vir...
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Article
Open AccessObesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus
Telomere shortening is associated with increasing age, male gender and lifestyle factors such as obesity and smoking. Inflammation has also been implicated in cellular senescence and may promote telomere short...
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Article
Precision prevention of oesophageal adenocarcinoma
The incidence of oesophageal adenocarcinoma has increased over the past four decades and although treatments have improved over this time, survival has not improved substantially. In this Perspectives, Vaughan...
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Article
From genomics to diagnostics of esophageal adenocarcinoma
The genetic determinants of progression from premalignant Barrett's esophagus to esophageal adenocarcinoma are not known. A new study reports genomic sequence analyses of this progression and uses the insights...
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Article
Intraindividual variability over time in plasma biomarkers of inflammation and effects of long-term storage
Systemic measures of chronic inflammation, often based on a single blood draw, are frequently used to study the associations between inflammation and chronic diseases such as cancer. However, more information ...
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Article
Open AccessQuantification of population benefit in evaluation of biomarkers: practical implications for disease detection and prevention
With the rapid development of “-omic” technologies, an increasing number of purported biomarkers have been identified for cancer and other diseases. The process of identifying those that are most promising and...
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Article
Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium
Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse ...
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Article
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus
Thomas Vaughan and colleagues report a genome-wide association study of esophageal adenocarcinoma together with its precancerous lesion, Barrett's esophagus. They identified three loci associated with suscepti...
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Article
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus
Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. ...
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Article
Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis
The paradigm that Barrett's oesophagus develops as a consequence of symptomatic gastroesophageal reflux disease and predisposes to oesophageal adenocarcinoma h...
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Article
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
A number of risk factors for esophageal and gastric cancers have emerged, yet little is known whether risk factors map to molecular tumor markers such as overexpression of the tumor suppressor TP53. Using a US mu...
