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Article
Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women’s Health Initiative Observational Study
Hysterectomy is associated with subsequent changes in circulating hormone levels, but the evidence of an association for tubal ligation is unclear. We evaluated whether circulating concentrations of androgens ...
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Article
Open AccessTemporal changes in mammographic breast density and breast cancer risk among women with benign breast disease
Benign breast disease (BBD) and high mammographic breast density (MBD) are prevalent and independent risk factors for invasive breast cancer. It has been suggested that temporal changes in MBD may impact futur...
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Article
Open AccessAddition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women
Previous work in European ancestry populations has shown that adding a polygenic risk score (PRS) to breast cancer risk prediction models based on epidemiologic factors results in better discriminatory perform...
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Article
Open AccessHost, reproductive, and lifestyle factors in relation to quantitative histologic metrics of the normal breast
Emerging data indicate that variations in quantitative epithelial and stromal tissue composition and their relative abundance in benign breast biopsies independently impact risk of future invasive breast cance...
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Article
Open AccessShort-term changes in ultrasound tomography measures of breast density and treatment-associated endocrine symptoms after tamoxifen therapy
Although breast density decline with tamoxifen therapy is associated with greater therapeutic benefit, limited data suggest that endocrine symptoms may also be associated with improved breast cancer outcomes. ...
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Article
Open AccessAssociations between quantitative measures of TDLU involution and breast tumor molecular subtypes among breast cancer cases in the Black Women’s Health Study: a case–case analysis
Terminal duct lobular units (TDLUs) are the structures in the breast that give rise to most breast cancers. Previous work has shown that TDLU involution is inversely associated with TDLU metrics, such as TDLU ...
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Article
Open AccessEstimating vaccine effectiveness against SARS-CoV-2 infection, hospitalization and death from ecologic data in Costa Rica
Clinical trials and individual-level observational data in Israel demonstrated approximately 95% effectiveness of mRNA-based vaccines against symptomatic SARS-CoV-2 infection. Individual-level data are not ava...
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Article
Open AccessCharacterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma
Extranodal natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy that has been etiologically linked to Epstein-Barr virus (EBV) infection, with EBV gene transcripts identified in almost all cases....
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Article
Open AccessAssociation between immunologic markers and cirrhosis in individuals with chronic hepatitis B
Host immune response and chronic inflammation associated with chronic hepatitis B virus (HBV) infection play a key role in the pathogenesis of liver diseases such as cirrhosis and hepatocellular carcinoma (HCC...
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Article
Open AccessMammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma, has been...
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Article
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival
Tissue miRNA can discriminate between esophageal adenocarcinoma (EA) and normal epithelium. However, no studies have examined a comprehensive panel of circulating miRNAs in relation to EA diagnosis and survival.
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Article
Open AccessInverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study
Falciparum and endemic Burkitt lymphoma (eBL) are co-endemic in Africa, but the malaria experience in eBL patients is unknown. A lower prevalence of falciparum has been reported in eBL patients, but those results...
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Article
Open AccessTranslating the immediate effects of S-Ketamine using hippocampal subfield analysis in healthy subjects-results of a randomized controlled trial
Antidepressant doses of ketamine rapidly facilitate synaptic plasticity and modify neuronal function within prefrontal and hippocampal circuits. However, most studies have demonstrated these effects in animal ...
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Article
Open AccessRisk factors for breast cancer development by tumor characteristics among women with benign breast disease
Among women diagnosed with invasive breast cancer, 30% have a prior diagnosis of benign breast disease (BBD). Thus, it is important to identify factors among BBD patients that elevate invasive cancer risk. In ...
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Article
Open AccessInflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of develo** gallbladder cancer
Chile has high incidence rates of gallbladder cancer globally, particularly among Amerindian women, who also have a high prevalence of gallstones. We examined differences in inflammatory biomarkers between Map...
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Article
Associations between daily aspirin use and cancer risk across strata of major cancer risk factors in two large U.S. cohorts
Daily aspirin use has been shown to reduce risk of colorectal, and possibly other, cancers, but it is unknown if these benefits are consistent across subgroups of people with differing cancer risk factors. We ...
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Article
Open AccessLeast squares and maximum likelihood estimation of sufficient reductions in regressions with matrix-valued predictors
We propose methods to estimate sufficient reductions in matrix-valued predictors for regression or classification. We assume that the first moment of the predictor matrix given the response can be decomposed i...
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Article
Open AccessUse of postmenopausal hormone therapies and risk of histology- and hormone receptor-defined breast cancer: results from a 15-year prospective analysis of NIH-AARP cohort
Menopausal hormone therapy (MHT) increases breast cancer (BC) risk, but cohort studies largely consider use only at enrollment. Evidence is limited on how changes in MHT use alter the magnitude of risk, and wh...
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Article
Risk factors for inflammatory and non-inflammatory breast cancer in North Africa
Studies of the etiology of inflammatory breast cancer (IBC), a rare but aggressive breast cancer, have been hampered by limited risk factor information. We extend previous studies by evaluating a broader range...
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Article
Obesity and related conditions and risk of inflammatory breast cancer: a nested case–control study
Inflammatory breast cancer (IBC) is a rare, poorly understood and aggressive tumor. We extended prior findings linking high body mass index (BMI) to substantial increased IBC risk by examining BMI associations...
