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Article
Open AccessExtrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer1–6. At present, it is unclea...
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Article
Open AccessMetaldehyde Transport Processes in a Water Abstraction Catchment in Essex, Southeast England
This paper addresses the issue of pesticide loss from agriculture and its impact on the aquatic environment. Specifically, this study assesses the transport of the relatively water-soluble polar molluscicide c...
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Article
Open AccessSomatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression
While the genomes of normal tissues undergo dynamic changes over time, little is understood about the temporal-spatial dynamics of genomes in premalignant tissues that progress to cancer compared to those that...
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Article
Rhizosphere microbiome modulated effects of biochar on ryegrass 15N uptake and rhizodeposited 13C allocation in soil
Incorporation of biochar into the soil sequesters C for millennia, but the concomitant effects on plant rhizodepositions and nutrient (e.g., nitrogen; N) trade-offs via interactions of heterotrophic microbiota...
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Article
Open AccessCorrection to: NSAID use and somatic exomic mutations in Barrett’s esophagus
It was highlighted that in the original article [1] the Availability of data and materials section was incorrect.
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Article
Advances in research on the use of biochar in soil for remediation: a review
Soil contamination mainly from human activities remains a major environmental problem in the contemporary world. Significant work has been undertaken to position biochar as a readily-available material useful ...
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Article
Open AccessNSAID use and somatic exomic mutations in Barrett’s esophagus
Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the metaplastic condition Barrett’s esophagus (...
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Article
Open AccessEvolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
The low risk of progression of Barrett’s esophagus (BE) to esophageal adenocarcinoma can lead to over-diagnosis and over-treatment of BE patients. This may be addressed through a better understanding of the dy...
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Article
A review of source tracking techniques for fine sediment within a catchment
Excessive transport of fine sediment, and its associated pollutants, can cause detrimental impacts in aquatic environments. It is therefore important to perform accurate sediment source apportionment to identi...
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Article
Mitigating cadmium accumulation in greenhouse lettuce production using biochar
Greenhouse experiments were conducted to investigate the influence of rice straw biochar (RSB) on soil cadmium (Cd) availability and accumulation in lettuce. The RSB was applied either in bands or broadcast in...
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Article
Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma
Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its prec...
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Article
Spatial distribution of soil hydraulic parameters estimated by pedotransfer functions for the Jialing River Catchment, Southwestern China
Soil hydraulic parameters θ s, α, n, K s, L and θ r of the van Genuchten-Mualem model were estimated using three ped...
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Article
Biochar increased water holding capacity but accelerated organic carbon leaching from a slo** farmland soil in China
A hydrologically contained field study, to assess biochar (produced from mixed crop straws) influence upon soil hydraulic properties and dissolved organic carbon (DOC) leaching, was conducted on a loamy soil (...
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Article
Open AccessObesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus
Telomere shortening is associated with increasing age, male gender and lifestyle factors such as obesity and smoking. Inflammation has also been implicated in cellular senescence and may promote telomere short...
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Article
Application of sewage sludge and sewage sludge biochar to reduce polycyclic aromatic hydrocarbons (PAH) and potentially toxic elements (PTE) accumulation in tomato
The effects of sewage sludge (SS) and its derived biochar (SSBC) on the availability and uptake of polycyclic aromatic hydrocarbons (PAHs) and potential toxic elements (PTEs) by Solanum lycopersicum (tomato) frui...
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Article
Mitigating heavy metal accumulation into rice (Oryza sativa L.) using biochar amendment — a field experiment in Hunan, China
A field experiment was conducted to investigate the effect of bean stalk (BBC) and rice straw (RBC) biochars on the bioavailability of metal(loid)s in soil and their accumulation into rice plants. Phytoavailab...
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Article
Intraindividual variability over time in plasma biomarkers of inflammation and effects of long-term storage
Systemic measures of chronic inflammation, often based on a single blood draw, are frequently used to study the associations between inflammation and chronic diseases such as cancer. However, more information ...
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Article
Open AccessQuantification of population benefit in evaluation of biomarkers: practical implications for disease detection and prevention
With the rapid development of “-omic” technologies, an increasing number of purported biomarkers have been identified for cancer and other diseases. The process of identifying those that are most promising and...
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Article
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus
Thomas Vaughan and colleagues report a genome-wide association study of esophageal adenocarcinoma together with its precancerous lesion, Barrett's esophagus. They identified three loci associated with suscepti...
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Article
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus
Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. ...
