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Article
Surgical Outcomes of Single-Port and Multiport Laparoscopic Resection for Gastric Gastrointestinal Stromal Tumors (GIST): a Single-Center Experience
Although single-port laparoscopic resection of gastrointestinal stromal tumor (GIST) offers advantages over multiport procedures in terms of reduced pain, faster recovery, and superior cosmetic results, its ef...
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Article
Open AccessInfluence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis
Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide data...
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Article
Open AccessJoint index vector: a novel assessment measure for stratified medicine in patients with rheumatoid arthritis
To predict the next-year status in patients with rheumatoid arthritis using big data.
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Chapter
Treatment of Neuropsychiatric Systemic Lupus Erythematosus
Systemic lupus erythematosus includes a wide range of neuropsychiatric manifestations, in which various autoantibodies and cytokines could play a pathophysiologic role. The key drugs used in the of neuropsyc...
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Article
Open AccessDecreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice
Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. PADI4 is highly expressed in the bone marrow, macrophage...
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Article
Open AccessHead-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the registry of Japanese RA patients on biologics for long-term safety (REAL) registry
The objective of this study was to directly compare the safety of tocilizumab (TCZ) and TNF inhibitors (TNFIs) in rheumatoid arthritis (RA) patients in clinical practice.
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Article
Open AccessNew molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee
The G-Project committee was erected by the Japan Society for Gastroenterological Carcinogenesis with an aim of establishing a new classification scheme based on molecular biological characteristics that would ...
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Article
Intranodal Lymphangiogenesis Precedes Development of Lymph Node Metastasis and Accelerates Progression of Gastric Cancer
Peritumoral lymphangiogenesis is significantly correlated with lymph node metastasis and poor prognosis in various cancers. However, there are few reports concerning the role of intranodal lymphangiogenesis in...
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Article
SPan-1 Is a Useful Prognostic Marker for Patients with Stage IV Gastric Cancer Who Underwent Palliative Gastrectomy: A Retrospective Multivariate Study
We retrospectively investigated prognostic factors to be used in selecting the patients with stage IV gastric cancer (GC) who have an unfavorable prognosis after palliative gastrectomy.
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Article
Open AccessClinical characteristics of neuro-Behcet’s disease in Japan: a multicenter retrospective analysis
To delineate the clinical characteristics of neuro-Behçet’s disease (NBD), a multicenter retrospective survey was performed in BD patients who had presented any neurological manifestations between 1988 and 200...
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Article
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Yuta Kochi and colleagues report a meta-analysis of genome-wide association studies for rheumatoid arthritis in a Japanese population. They identify nine loci newly associated with rheumatoid arthritis in this...
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Article
Borrmann’s Macroscopic Criteria and p-Smad2 Expression Are Useful Predictive Prognostic Markers for Cytology-Positive Gastric Cancer Patients Without Overt Peritoneal Metastasis
All patients with peritoneal-free cancer cells (CY1) do not always develop a peritoneal recurrence (P1). The goal of this study was to identify characteristic features of peritoneal-free cancer cells that coul...
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Article
Open AccessDetection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis
Anti-citrullinated protein/peptide antibodies (ACPAs) are highly specific to rheumatoid arthritis (RA) patients and are thought to have a close relationship with the pathogenesis of arthritis. Several proteins...
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Article
Severe headache complicated by vertical atlantoaxial subluxation in diffuse systemic sclerosis with crowned dens pattern calcification
We report a 34-year-old female case of diffuse systemic sclerosis (SSc) with generalized ectopic calcification, who developed severe headache with vertical atlantoaxial subluxation (AAS) complicated by calcifi...
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Article
Open AccessPhosphorylated Smad2 in Advanced Stage Gastric Carcinoma
Transforming growth factor β (TGFβ) receptor signaling is closely associated with the invasion ability of gastric cancer cells. Although Smad signal is a critical integrator of TGFβ receptor signaling transduc...
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Article
Open AccessRNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells
MUC5AC is a secretory mucin normally expressed in the surface muconous cells of stomach and bronchial tract. It has been known that MUC5AC de novo expression occurred in the invasive ductal carcinoma and pancreat...
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Article
Chronic myeloid leukemia in two patients with gastrointestinal stromal tumor
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Article
Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis
Among the 5,043 consecutive patients registered in the postmarketing surveillance for leflunomide, 61 were reported to have lung injury and 24 died from it. The adjusted multivariate logistic regression analys...
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Article
Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population
Kazuhiko Yamamoto and colleagues report an association of two SNPs in CD244 with increased risk of rheumatoid arthritis. These variants promote increased expression of CD244 in luciferase reporter assays.
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Article
Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios
The objective of this study was to assess both the anti-inflammatory and immunomodulatory effects of low-dosage simvastatin on rheumatoid arthritis (RA). In each patient, simvastatin at 10 mg/day was administe...
