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Article
Activation of the ATR kinase by the RPA-binding protein ETAA1
Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation o...
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Chapter and Conference Paper
Rotating Sonar: Modeling and Application
In this paper, the modeling and application of a rotating ultrasonic range sensor are described. Rather than employing a ring of ultrasonic sensors around the perimeter of a mobile robot platform, a single rot...
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Article
Cyclic hexapeptide antagonists of the bradykinin B2 receptor: Receptor binding and solution backbone conformation
Cyclic hexapeptide analogs of bradykinin, based on a folded receptor-bound model of bradykinin, were found to be able to antagonize the action of bradykinin at its B2 bradykinin receptor. The best of these, cyclo...
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Article
Therapeutic effects of a synthetic peptide of C-reactive protein in pre-clinical tumor models
Previous studies have shown that multilamellar vesicles (MLV) or other carriers containing purified human C-reactive protein (CRP) have therapeutic activity in preclinical tumor models. Here we evaluated the t...