5 Result(s)
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Maxim A. X. Tollenaere
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Article
Open Accessp38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Ultraviolet (UV) light radiation induces the formation of bulky photoproducts in the DNA that globally affect transcription and splicing. However, the signaling pathways and mechanisms that link UV-light-induc...
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Article
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Hansen et al. find that SCAI (suppressor of cancer cell invasion) is a 53BP1-binding protein that acts to repair in heterochromatin and to facilitate meiotic recombination in germ cells.
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Article
Activation of the ATR kinase by the RPA-binding protein ETAA1
Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation o...
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Article
Open Accessp38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1
Centriolar satellites (CS) are small granular structures that cluster in the vicinity of centrosomes. CS are highly susceptible to stress stimuli, triggering abrupt displacement of key CS factors. Here we disc...
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Article
Centriolar satellites: key mediators of centrosome functions
Centriolar satellites are small, microscopically visible granules that cluster around centrosomes. These structures, which contain numerous proteins directly involved in centrosome maintenance, ciliogenesis, a...
