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  1. Article

    Open Access

    Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

    Protein SUMOylation provides a principal driving force for cellular stress responses, including DNA–protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using genome-scale sc...

    Julio C. Y. Liu, Leena Ackermann, Saskia Hoffmann… in Nature Structural & Molecular Biology (2024)

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    Article

    Activation of the ATR kinase by the RPA-binding protein ETAA1

    Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation o...

    Peter Haahr, Saskia Hoffmann, Maxim A. X. Tollenaere, Teresa Ho… in Nature Cell Biology (2016)

  3. No Access

    Article

    FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

    The molecular events occurring following the disruption of DNA replication forks are poorly characterized, despite extensive use of replication inhibitors such as hydroxyurea in the treatment of malignancies. ...

    Kasper Fugger, Wai Kit Chu, Peter Haahr, Arne Nedergaard Kousholt… in Nature Communications (2013)