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  1. Article

    Open Access

    Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts

    Heat shock protein (HSP) 90 functions as a molecular chaperone and is constitutively expressed and induced in response to stress in many cell types. We have previously demonstrated that transforming growth fac...

    Gen Kuroyanagi, Haruhiko Tokuda, Kazuhiko Fujita in BMC Musculoskeletal Disorders (2022)

  2. No Access

    Article

    Bone parameters of elite athletes with oligomenorrhea and prevalence seeking medical attention: a cross-sectional study

    Since the definition of secondary amenorrhea is cessation of regular menses for more than 3 months, it is likely that athletes with irregular menstrual cycles, including oligomenorrhea, do not consider the con...

    Yuka Tsukahara, Suguru Torii, Fumihiro Yamasawa in Journal of Bone and Mineral Metabolism (2021)

  3. Article

    Open Access

    HSP22 (HSPB8) positively regulates PGF2α-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts

    Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling ...

    Gen Kuroyanagi, Go Sakai, Takanobu Otsuka in Journal of Orthopaedic Surgery and Research (2021)

  4. No Access

    Chapter and Conference Paper

    Identifying Anomaly Work in Intralogistics Using BLE and LPWA

    Due to recent increased competition in the automobile industry, many studies have optimized manufacturing models to reduce costs. However, such studies have produced scant benefits because these models have ma...

    Masahiro Yamaguchi, Noriko Yuasa in Advances and Trends in Artificial Intellig… (2021)

  5. Article

    Open Access

    Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis

    The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy ...

    Shiro Saito, Hisaki Aiba, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi in BMC Cancer (2020)

  6. Article

    Open Access

    Incretin accelerates platelet-derived growth factor-BB-induced osteoblast migration via protein kinase A: The upregulation of p38 MAP kinase

    Incretins, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), secreted from enteroendocrine cells after food ingestion, are currently recognized to regulate gluco...

    Tetsu Kawabata, Haruhiko Tokuda, Gen Kuroyanagi, Kazuhiko Fujita in Scientific Reports (2020)

  7. Article

    Open Access

    Local dissemination of osteosarcoma observed after massage therapy: a case report

    Limited evidence is available regarding the dissemination of tumor tissues due to compression during massage therapy, a routine procedure in patients with various symptoms in Asian countries.

    Shinji Miwa, Michi Kamei, Satoru Yoshida, Satoshi Yamada, Hisaki Aiba in BMC Cancer (2019)

  8. No Access

    Article

    Reproducibility of acquiring ultrasonographic infant hip images by the Graf method after an infant hip ultrasound training course

    The objective screening of infant hips using ultrasonography (Graf method) is gaining favor in the diagnosis of developmental dysplasia of the hip in Japan. However, the accuracy of the Graf method is dependen...

    Yasuhiro Shirai, Kenjiro Wakabayashi, Ikuo Wada in Journal of Medical Ultrasonics (2018)

  9. Article

    Open Access

    Treatment of aneurysmal bone cysts using endoscopic curettage

    Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy,...

    Hisaki Aiba, Masaaki Kobayashi, Yuko Waguri-Nagaya in BMC Musculoskeletal Disorders (2018)

  10. Article

    Open Access

    Treatment of simple bone cysts using endoscopic curettage: a case series analysis

    Endoscopic curettage is considered applicable for the treatment of simple bone cysts with the expectation that it might be less invasive than open curettage. In this study, we investigated the efficacy of endo...

    Hisaki Aiba, Masaaki Kobayashi in Journal of Orthopaedic Surgery and Research (2018)

  11. No Access

    Article

    Post-operative rotator cuff integrity, based on Sugaya’s classification, can reflect abduction muscle strength of the shoulder

    Magnetic resonance (MR) imaging is common in structural and qualitative assessment of the rotator cuff post-operatively. Rotator cuff integrity has been thought to be associated with clinical outcome. The pur...

    Masahito Yoshida, Phillipe Collin in Knee Surgery, Sports Traumatology, Arthros… (2018)

  12. No Access

    Article

    Spontaneous shrinkage of solitary osteochondromas

    Osteochondromas are the most common benign bone tumors, and thus far, their spontaneous shrinkage is considered a rare phenomenon. This study was designed to investigate the exact ratio of remission to progres...

    Hisaki Aiba, Satoshi Yamada, Norio Yamamoto, Katsuhiro Hayashi in Skeletal Radiology (2018)

  13. No Access

    Chapter and Conference Paper

    An Implementation of Large-Scale Holonic Multi-agent Society Simulator and Agent Behavior Model

    This paper presents a large-scale multiagent simulator that can simulate any complex urban environment and demonstrates its implementation on a distributed computing environment. We focus on society simulation...

    Takayuki Ito, Takanobu Otsuka in PRICAI 2018: Trends in Artificial Intellig… (2018)

  14. No Access

    Chapter and Conference Paper

    An Innovative Outdoor IoT System Architecture for Service Oriented Things

    In recent years, Internet of Things (IoT) has widely studied as a technology using the Wireless Sensor Networks (WSNs). The essential purpose of WSN is is the availability of the sensor stream. In addition, Io...

    Takanobu Otsuka, Yoshitaka Torii in Recent Advances and Future Prospects in Kn… (2018)

  15. No Access

    Chapter and Conference Paper

    Towards Machine Learning Based IoT Intrusion Detection Service

    IoT Security is one of the most critical issues when develo**, implementing and deploying IoT platforms. IoT refers to the ability of communication, monitoring and remote control of automated devices through...

    TagyAldeen Mohamed, Takanobu Otsuka in Recent Trends and Future Technology in App… (2018)

  16. No Access

    Chapter and Conference Paper

    Multiple Water-Level Seawater Temperature Prediction Method for Marine Aquaculture

    The importance of aquaculture continues to grow due to the decrease in natural marine resources and an increase in worldwide demand. To avoid losses from aging and abnormal weather, we must predict multiple wa...

    Takanobu Otsuka, Yuji Kitazawa, Takayuki Ito in Recent Trends and Future Technology in App… (2018)

  17. Article

    Open Access

    Design of Joint Cooperative Routing, MAC and Physical Layer with QoS-aware Traffic-based Scheduling for Wireless Sensor Networks

    Compare the WSN with other conventional network system, the changing or charging the existing battery of sensor node within WSN is a tough job. Therefore, since last decade the effort has been made to design a...

    Jawad Ahmad Haqbeen, Takayuki Ito in International Journal of Networked and Dis… (2017)

  18. Article

    Open Access

    An Intelligent Cross-Layer QoS-Aware Protocol with Traffic-Differentiation-Based for Energy Efficient Communication in WSNs

    Despite an increase in energy efficiency of WSNs research in couple of last years, still the key challenge in the design of WSNs remains to maximize the quality of service (QoS) and energy efficiency of networ...

    Jawad Ahmad Haqbeen, Takayuki Ito in International Journal of Networked and Dis… (2017)

  19. No Access

    Chapter and Conference Paper

    Technical Challenges and Implementation of Mobile Ad-hoc Water Level Measuring System

    In recent years, and landslides caused by flooding of the river due to heavy rain, the number of such flooding of houses has increased. With regard to internal water damage, the structure and of the river, abo...

    Takanobu Otsuka, Yoshitaka Torii, Takayuki Ito in Multi-agent and Complex Systems (2017)

  20. No Access

    Article

    Prediction of skeletal-related events in patients with non-small cell lung cancer

    Advanced lung cancer frequently causes bone metastasis which can be associated with skeletal-related events (SREs) that may cause significant deterioration of the patient’s quality of life (QoL). The Spinal In...

    Hisaki Aiba, Tomoki Kimura, Takaya Yamagami, Nobuyuki Watanabe in Supportive Care in Cancer (2016)

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