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Article
Open AccessBone scan index (BSI) scoring by using bone scintigraphy and circulating tumor cells (CTCs): predictive factors for enzalutamide effectiveness in patients with castration-resistant prostate cancer and bone metastases
Reports of Bone Scan Index (BSI) calculations as imaging biomarkers to predict survival in patients with metastatic castration-resistant prostate cancer (mCRPC) have been mainly from retrospective studies. To ...
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Article
Light is an Important Limiting Factor for the Vertical Distribution of the Largest Extant Benthic Foraminifer Cycloclypeus carpenteri
Cycloclypeus carpenteri is the largest extant benthic foraminifer, dwelling in the deep euphotic zone (a water depth between 60 and 130 m) of the warm oligotrophic Indo-West Pacific. This foraminifer harbors diat...
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Article
Open AccessUpregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts
Heat shock protein (HSP) 90 functions as a molecular chaperone and is constitutively expressed and induced in response to stress in many cell types. We have previously demonstrated that transforming growth fac...
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Article
Open AccessThe coral reef-dwelling Peneroplis spp. shows calcification recovery to ocean acidification conditions
Large Benthic Foraminifera are a crucial component of coral-reef ecosystems, which are currently threatened by ocean acidification. We conducted culture experiments to evaluate the impact of low pH on survival...
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Article
Open AccessTrophic niche separation of two non-spinose planktonic foraminifers Neogloboquadrina dutertrei and Pulleniatina obliquiloculata
Based on laboratory observations, planktonic foraminifers are omnivorous, feeding zooplankton and phytoplankton. Spinose species tend toward greater dependence on zooplankton prey than on phytoplankton prey, w...
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Article
Open AccessDecrease in volume and density of foraminiferal shells with progressing ocean acidification
Rapid increases in anthropogenic atmospheric CO2 partial pressure have led to a decrease in the pH of seawater. Calcifying organisms generally respond negatively to ocean acidification. Foraminifera are one of th...
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Article
Open AccessHSP22 (HSPB8) positively regulates PGF2α-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts
Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling ...
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Article
Open AccessIncretin accelerates platelet-derived growth factor-BB-induced osteoblast migration via protein kinase A: The upregulation of p38 MAP kinase
Incretins, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), secreted from enteroendocrine cells after food ingestion, are currently recognized to regulate gluco...
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Article
Open AccessPerspective on the response of marine calcifiers to global warming and ocean acidification—Behavior of corals and foraminifera in a high CO2 world “hot house”
The CO2 concentration of air has increased over the last two centuries and recently surpassed 400 ppm. Carbon cycle models project CO2 concentrations of 720 to 1000 ppm for the IPCC intermediate scenario (RCP 6.0...
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Article
Rapid glaciation and a two-step sea level plunge into the Last Glacial Maximum
The approximately 10,000-year-long Last Glacial Maximum, before the termination of the last ice age, was the coldest period in Earth’s recent climate history1. Relative to the Holocene epoch, atmospheric carbon d...
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Article
Response of the Great Barrier Reef to sea-level and environmental changes over the past 30,000 years
Previous drilling through submerged fossil coral reefs has greatly improved our understanding of the general pattern of sea-level change since the Last Glacial Maximum, however, how reefs responded to these ch...
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Article
Open AccessProton pum** accompanies calcification in foraminifera
Ongoing ocean acidification is widely reported to reduce the ability of calcifying marine organisms to produce their shells and skeletons. Whereas increased dissolution due to acidification is a largely inorga...
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Article
Shell productivity of the large benthic foraminifer Baculogypsina sphaerulata, based on the population dynamics in a tropical reef environment
Carbonate production by large benthic foraminifers is sometimes comparable to that of corals and coralline algae, and contributes to sedimentation on reef islands and beaches in the tropical Pacific. Populatio...
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Article
Prediction of bending stiffness and moment carrying capacity of sugi cross-laminated timber
Cross-laminated timber (CLT) panels consist of several layers of lumber stacked crosswise and glued together on their faces. Prototype sugi CLT floor panels were manufactured and bending tests were carried out...
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Article
Estimating photophysiological condition of endosymbiont-bearing Baculogypsina sphaerulata based on the holobiont color represented in CIE L*a*b* color space
Symbiont-bearing large benthic foraminifers (LBFs) are widely distributed around coral reefs. If the physiological responses of LBFs to environmental changes can be recognized at an individual level, LBFs coul...
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Article
Distribution of gravel-sized empty tests of large benthic foraminifers as practical depositional indicators in tropical reef and shelf carbonate environments
To explore the utility of gravel-sized tests of large benthic foraminifers (LBFs) as practical paleoenvironmental indicators of tropical reef and shelf carbonate environments, depth and spatial distributions o...
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Article
Simulation method to generate the strength of glulam using correlated random variables
Many reports have been published about designing the strength of glulam using simulation methods. In simulation methods, one of the most important problems is how to deal with correlations among strength facto...
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Article
Absence of correlation of MUC1 expression to malignant behavior of renal cell carcinoma in experimental systems
A correlation between MUC1 expression in renal cell carcinomas (RCCs) and the clinical stages was previously demonstrated. To assess whether MUC1 expression is causally related to malignant tumor behavior, MUC...
