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157 Result(s)
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Tae-** Yang
Life Sciences
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Article
Improved biomass and metabolite production in hairy root culture in various genotypes of Panax ginseng through genetic transformation
The economic important medicinal plant, Panax ginseng, encompasses a diverse array of pharmacologically beneficial ginsenosides governed by complex metabolic pathways. The cultivation of P. ginseng over an extend...
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Article
A designer peptide against the EAG2–Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma
Glioblastoma (GBM) is an incurable brain cancer that lacks effective therapies. Here we show that EAG2 and Kvβ2, which are predominantly expressed by GBM cells at the tumor–brain interface, physically interact...
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Article
Open AccessAhnak is required to balance calcium ion homeostasis and smooth muscle development in the urinary system
Various renal abnormalities, including hydronephrosis, polycystic kidney disease, and hydroureter, have been reported, and these abnormalities are present in DiGeorge syndrome, renal dysplasia, and acute kidne...
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Article
Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis
Panax ginseng is a medicinal plant belonging to the Araliaceae family. Ginseng is known as the king of oriental medicine, which has been practiced since ancient times in East Asian countries and globally in the m...
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Article
Open AccessStepwise molecular mechanisms responsible for chemoresistance in bladder cancer cells
Chemotherapy resistance is an obstacle to cancer therapy and is considered a major cause of recurrence. Thus, understanding the mechanisms of chemoresistance is critical to improving the prognosis of patients....
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Article
Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases
Hundreds of leucine-rich repeat receptor kinases (LRR-RKs) have evolved to control diverse processes of growth, development and immunity in plants, but the mechanisms that link LRR-RKs to distinct cellular res...
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Article
Development of expressed sequence tag simple sequence repeat (EST-SSR) markers and genetic resource analysis of tea oil plants (Camellia spp.)
Tea oil plants are economically valuable as a chemical feedstock, a bioenergy source, and a dietary supplement. The lack of molecular markers for genetic resource clustering for conservation restricts research...
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Article
Open AccessEpimorphic regeneration of the mouse digit tip is finite
Structural regeneration of amputated appendages by blastema-mediated, epimorphic regeneration is a process whose mechanisms are beginning to be employed for inducing regeneration. While epimorphic regeneration...
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Article
Cell cycle synchronization in Panax ginseng roots for cytogenomics research
Although molecular cytogenomic data have contributed to elucidating the organization of the Panax ginseng genome, progress in cytogenomics research has been slow because of compounding factors like seasonal avail...
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Article
Open AccessGenome structure and diversity among Cynanchum wilfordii accessions
Cynanchum wilfordii (Cw) and Cynanchum auriculatum (Ca) have long been used in traditional medicine and as functional food in Korea and China, respectively. They have diverse medicinal functions, and many studies...
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Article
Open AccessSALM4 negatively regulates NMDA receptor function and fear memory consolidation
Many synaptic adhesion molecules positively regulate synapse development and function, but relatively little is known about negative regulation. SALM4/Lrfn3 (synaptic adhesion-like molecule 4/leucine rich repe...
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Article
Open AccessDynamic evolution of Panax species
Panax ginseng is one of the most valuable medicinal plants in Korea. However, deciphering its full genome sequence information for crop improvement has been hampered due to its complex genomic, genetic, and growt...
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Article
Open AccessApoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activation
Apoptosis inhibitor of macrophage (AIM) modulates the signaling in inflammatory responses, including infection, cancer, or other immune diseases. Recent studies suggest that like interleukin-10 (IL-10), AIM is...
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Book
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Chapter
Ginseng Genome Structure and Evolution
Ginseng (Panax ginseng) genome has been difficult to unlock its genomics due to its size, high repeat content, and polyploidy nature. Although chromosome-scale genome assembly for ginseng holds numerous challenge...
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Chapter
Genomic Resources for Ginseng Genome Studies
Advances in sequencing technologies have enabled scientists to sequence both DNA and RNA molecules from ginseng (Panax ginseng) and its close relatives. These datasets include transcriptome of various tissues and...
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Protocol
Mining of Miniature Transposable Elements in Brassica Species at BrassicaTED
Miniature form transposable elements (mTEs) are ubiquitous in plant genomes and directly linked to gene regulation and evolution. With the advantage of completely sequenced genomes of Brassica rapa and Brassica o...
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Chapter
Breeding of Superior Ginseng Cultivars
There is a total of 32 ginseng cultivating varieties (cultivars) in Korea which have unique agronomic and morphological traits. Each variety was registered as an official cultivar and protected for breeder’s r...
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Chapter
Chloroplast Genome Diversity in Panax Genus
The chloroplast genome variation between plant species and individuals is especially valuable for studying plant genome diversity. Recently, 45S rDNA and the complete chloroplast genome sequences from seven Panax
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Chapter
Molecular Cytogenetics of Panax Ginseng
While the medicinal importance of Panax ginseng has long been established, its molecular cytogenetic data have not been available until the recent decade. Slow growth, low seed yield, long seed dormancy, sensitiv...
