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Article
Open AccessReal-world treatment patterns and outcomes of abemaciclib for the treatment of HR + , HER2- metastatic breast cancer patients in Japan
This study described, in routine clinical practice in Japan, the patient characteristics, treatment patterns, and outcomes of female patients with HR + /HER2- metastatic breast cancer (MBC) who started abemaci...
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Article
Open AccessEfficacy and safety of trastuzumab, lapatinib, and paclitaxel neoadjuvant treatment with or without prolonged exposure to anti-HER2 therapy, and with or without hormone therapy for HER2-positive primary breast cancer: a randomised, five-arm, multicentre, open-label phase II trial
Dual blockade of HER2 promises increased pathological complete response (pCR) rate compared with single blockade in the presence of chemotherapy for HER2-positive (+) primary breast cancer. Many questions rema...
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Article
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis
Astrocytes are known to facilitate repair following brain injury; however, little is known about how injured astrocytes repair themselves. Repair of cell membrane injury requires Ca2+-triggered vesicle exocytosis...
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Article
Biological index of environmental lead pollution: accumulation of lead in liver and kidney in mice
Lead (Pb) is known to be highly poisonous, and the acute poisoning of Cd causes the abdominal pains, vomiting, and shock. The digestive and nervous symptom is observed in the chronic lead poisoning. It was als...
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Article
A phase II study of metronomic paclitaxel/cyclophosphamide/capecitabine followed by 5-fluorouracil/epirubicin/cyclophosphamide as preoperative chemotherapy for triple-negative or low hormone receptor expressing/HER2-negative primary breast cancer
Better treatments for triple-negative breast cancer (TNBC) are needed. To address this need, we studied the effects of preoperative metronomic paclitaxel/cyclophosphamide/capecitabine (mPCX) followed by 5-fluo...
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Article
Open AccessEarly and mid-term results of transapical and right axillary artery cannulation for acute aortic dissection
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Open AccessAortic regurgitation and aortic valve replacement during repair of acute aortic dissection
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Open AccessEarly results of aortic root reoperation
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Article
Measurement schemes for the spin quadratures on an ensemble of atoms
We consider how to measure collective spin states of an atomic ensemble based on the multi-pass approaches for quantum interface between light and atoms. We find that a scheme with two passages of a light puls...
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Article
Occurrence of asymmetrical flow pattern behind an orifice in a circular pipe
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Article
Open AccessCytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection
We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly h...
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Article
Antenatal magnesium sulfate and the postnatal response of the ductus arteriosus to indomethacin in extremely preterm neonates
The aim of this study is to evaluate the influence of antenatal magnesium sulfate (MgSO4) treatment on the clinical responsiveness of the ductus arteriosus to indomethacin prophylaxis and on that of symptomatic p...
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Article
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.
Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine. We found that adenosine,...
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Article
Usefulness of Gram staining of tracheal aspirates in initial therapy for ventilator-associated pneumonia in extremely preterm neonates
To determine the effectiveness of Gram staining of tracheal aspirates for predicting causative microorganisms and guiding appropriate initial antibiotic therapy to treat ventilator-associated pneumonia (VAP) i...
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Article
The effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly subjects
To study the effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly healthy subjects.
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Article
The Noise and Energy Resolution of the Ti/Au Bilayer X-ray TES Calorimeter with an Au Absorber
We fabricated the TES microcalorimeter with TES(Ti/Au) and gold absorber, and obtained FWHM energy resolution of 4.8±0.3 eV at 5.9 keV. The baseline resolution, i.e. the resolution determined by noise, was 4.1...
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Synthesis, Phase Diagram, and Evolution of Electronic Properties in LixZrNCl Superconductors
We succeed in synthesizing a series of single phase LixZrNCl samples with controlled do** levels (0 ≤ x ≤ 0.31) by adopting an appropriate annealing procedure for lightly doped samples. An insulator-to-supercon...
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Article
Open AccessBRAFV600E mutation in anaplastic thyroid carcinomas and their accompanying differentiated carcinomas
Frequency of a BRAFV600E mutation in anaplastic thyroid carcinoma, which is thought to be derived mainly from papillary carcinoma by multi-step carcinogenesis, is much lower than that in papillary carcinomas. To ...
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Article
Open AccessClinical outcome and risk factors for recurrence in borderline ovarian tumours
We investigated the long-term prognosis of borderline ovarian tumours and determined risk factors for recurrence. One hundred and twenty-one borderline ovarian tumours treated between 1994 and 2003 at the part...
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Article
Paramagnetic Faraday rotation with spin-polarized ytterbium atoms
We report the observation of paramagnetic Faraday rotation of spin-polarized ytterbium (Yb) atoms. As the atomic samples, we used an atomic beam, released atoms from a magneto-optical trap (MOT), and trapped a...
