-
Article
Open AccessFluoropyrimidine type, patient age, tumour sidedness and mutation status as determinants of benefit in patients with metastatic colorectal cancer treated with EGFR monoclonal antibodies: individual patient data pooled analysis of randomised trials from the ARCAD database
KRAS mutations in metastatic colorectal cancer (mCRC) are used as predictive biomarkers to select therapy with EGFR monoclonal antibodies (mAbs). Other factors may be significant determinants of benefit.
-
Article
Thermal expansion of natural mantle spinel using in situ synchrotron X-ray powder diffraction
We used in situ measurements of X-ray diffraction patterns in a cubic multi-anvil press at pressures up to 3 GPa and at 500–1300 K to examine thermal expansion and its pressure dependence in (Mg0.73Fe0.27)(Cr0.56
-
Article
Open AccessComparison of the efficacy between continuoushemodiafiltration with polymethylmethacrylate (PMMA) membrane hemofilter CH-1.8W® and with pmma membrane dialyzer BK-2.1P® in the treatment of critically ill patients
-
Article
Histidine-rich glycoprotein prevents septic lethality through neutrophil regulation
-
Article
Mössbauer spectrum of high-pressure synthesized ilmenite-type FeGeO3
Ilmenite-type FeGeO3 was prepared by high-pressure synthesis technique using a Kawai-type multi-anvil apparatus at 23.5 GPa and 500 °C. The effects of post annealing on the high-pressure synthesized samples were ...
-
Article
Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology
-
Article
Open AccessReply: KRAS mutation in colorectal cancer metastases after adjuvant folfox for the primary
-
Article
Open AccessKRAS mutations in primary tumours and post-FOLFOX metastatic lesions in cases of colorectal cancer
KRAS mutations are predictive markers for the efficacy of anti-EGFR antibody therapies in patients with metastatic colorectal cancer. Although the mutational status of KRAS is reportedly highly concordant between...
-
Article
Open AccessPhase I study of TAS-102 treatment in Japanese patients with advanced solid tumours
TAS-102 consists of α, α, α-trifluorothymidine (TFT) and an inhibitor of thymidine phosphorylase (TPI). We conducted a dose-escalation phase I study in Japanese patients with advanced solid tumours.
-
Article
Phase 1 study of conatumumab, a pro-apoptotic death receptor 5 agonist antibody, in Japanese patients with advanced solid tumors
Conatumumab is a fully human monoclonal agonist antibody against human death receptor 5 (DR5). The primary objectives of this phase 1 study were to assess the safety, tolerability, and pharmacokinetics (PK) of...
-
Article
Open AccessKRAS mutations detected by the amplification refractory mutation system–Scorpion assays strongly correlate with therapeutic effect of cetuximab
We aimed to compare the sensitive and quality-controlled KRAS testing with direct sequencing and to assess the impact on decision making of treatment.
-
Article
Open AccessRefined human artificial chromosome vectors for gene therapy and animal transgenesis
Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance, and the ability to carry large gene inserts. We previously developed HAC vectors from...
-
Article
Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice
Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP appro...
-
Article
EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization
The ecotropic viral integration site-1 (EVI-1) is a nuclear transcription factor and has an essential function in the proliferation/maintenance of haematopoietic stem cells. Aberrant expression of EVI-1 has be...
-
Article
Parasitic nematodes of anseriform birds in Hokkaido, Japan
Parasitic nematodes of 176 individuals of 15 bird species belonging to the order Anseriformes from Hokkaido, Japan were investigated. A total of 12 nematode species were obtained, namely Amidostomum anseris, A. a...
-
Article
Cutaneous lymphocyte antigen-positive T cells may predict the development of acute GVHD: alterations and differences of CLA+ T- and NK-cell fractions
Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lym...
-
Article
Effect of On-Chip Magnetic Shielding for TES Microcalorimeters
We investigated the magnet field dependence of the X-ray pulse height and the critical current of a Ti/Au bilayer TES micro-calorimeter. The pulse height was strongly affected by the magnetic field intensity a...
-
Article
The Noise and Energy Resolution of the Ti/Au Bilayer X-ray TES Calorimeter with an Au Absorber
We fabricated the TES microcalorimeter with TES(Ti/Au) and gold absorber, and obtained FWHM energy resolution of 4.8±0.3 eV at 5.9 keV. The baseline resolution, i.e. the resolution determined by noise, was 4.1...
-
Article
Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome
Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance that avoids insertional mutations and the ability to carry large gene inserts includin...
-
Article
Short note: Crustal deformation in the key stone network detected by satellite laser ranging
The paper presents the results of crustal deformation, as evidenced by changed station coordinates, in the Tokyo metropolitan area detected by the satellite laser ranging (SLR) technique. The coordinates of tw...
