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Article
Open AccessHuman Brain Organoid Research and Applications: Where and How to Meet Legal Challenges?
An ethical and legal framework is needed to regulate the rapidly develo** human brain organoid research field properly. However, considering the legal issues involved in human brain organoid research remains...
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Article
Open AccessMeasuring Residual Strain and Stress in Thermal Spray Coatings Using Neutron Diffractometers
During thermal spray coating, residual strain is formed within the coating and substrates due to thermo-mechanical processes and microstructural phase changes.
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Article
Open AccessTemperature-Dependent Misfit Stress in Gamma Double Prime Strengthened Ni-Base Superalloys
Misfit stresses in the γ″-strengthened Ni-base superalloy Inconel 718 were calculated from the measured constrained misfit strain using Eshelby’s inclusion method. The constrained misfit strains of the γ″ precipi...
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Article
Open AccessEvolution of Lattice Spacing of Gamma Double Prime Precipitates During Aging of Polycrystalline Ni-Base Superalloys: An In Situ Investigation
Polycrystalline Ni-base superalloy Inconel 718 derives the strengthening mainly from Ni3Nb γ″ phase. To investigate the evolution of lattice spacing of γ″ precipitates, in situ neutron diffraction experiments wer...
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Article
Open AccessUsing Variant Selection to Facilitate Accurate Fitting of γ″ Peaks in Neutron Diffraction
γ″ diffraction peaks are hard to discern in neutron/X-ray diffraction patterns, hindering studies on the γ″-strengthened superalloys using in-situ diffraction. In this study, we propose a variant selection method...
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Article
Open AccessQuantifying the critical thickness of electron hybridization in spintronics materials
In the rapidly growing field of spintronics, simultaneous control of electronic and magnetic properties is essential, and the perspective of building novel phases is directly linked to the control of tuning pa...
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Article
Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease
Inflammatory bowel disease is well recognized for a strong genetic involvement in its pathogenesis. Homozygous mutations in interleukin-10 receptor 1 (IL-10R1) identified by linkage analysis were shown to be i...
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Article
Methylation of an intronic region regulates miR-199a in testicular tumor malignancy
In the testicular cancer cell line, NT2, we previously demonstrated that differentially methylated regions were located in introns or intergenic regions, and postulated these might regulate non-coding RNAs. Th...
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Article
Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese
UHRF1BP1 encodes a highly conserved protein with unknown function. Previously, a coding variant in this gene was found to be associated with systemic lupus erythematosus (SLE) in populations of European ancestry ...
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Article
Open AccessGenome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer
Testicular germ cell tumour (TGCT) is the most common malignant tumour in young males. Although aberrant DNA methylation is implicated in the pathophysiology of many cancers, only a limited number of genes are...
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Article
Open AccessAssociation of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Recently, single nucleotide polymorphisms (SNPs) in BANK1 and TNFSF4 have been shown to be associated with S...
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Article
Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
In this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SL...
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Article
HOM4PS-2.0: a software package for solving polynomial systems by the polyhedral homotopy continuation method
HOM4PS-2.0 is a software package in FORTRAN 90 which implements the polyhedral homotopy continuation method for solving polynomial systems. It updates its original version HOM4PS in three key aspects: (1) new ...
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Article
Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation
A cohort of 138 children with 144 hematopoietic stem cell transplantation (HSCT) performed in 1997–2006 were analyzed to evaluate risk factors and mortality predictors of hepatic veno-occlusive disease (VOD). ...
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Article
Neural Network Modeling for Estimation of Scour Depth Around Bridge Piers
It is essential to predict the scour depth around bridge piers for hydraulic engineers involved in the economical design of bridge pier foundation. Conventional investigations have long been of the opinion tha...
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Chapter and Conference Paper
Modeling and Characterization of Advanced Phosphorus Ultra Shallow Junction Using Germanium and Carbon Coimplants
A continuum model of phosphorus diffusion with germanium and carbon coimplant has been proposed and calibrated based on secondary ion mass spectroscopy (SIMS) profiles aiming at ultra shallow junction (USJ) fo...
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Article
Initial corrosion observed on the atomic scale
Electrochemical corrosion creates problems for engineers, and destroys over 3% of the world's GDP. But decomposition processes can be useful too, for example in the formation of porous metals. For good or ill,...
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Article
X-ray standing wave investigations of Si dopant incorporation in GaN
The synchrotron radiation technique of x-ray standing waves (XSW), which allows to directly obtain structural and element-specific data, was successfully used for the investigation of the dopant site distribut...
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Article
Use of midazolam and ketamine as sedation for children undergoing minor operative procedures
We used intravenous midazolam and ketamine for children undergoing minor operative procedures with satisfactory results. We aimed to further evaluate its efficacy and adverse effects in pediatric ward setting.
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Article
Antirecipient helper and cytotoxic T-cell frequencies in bone marrow transplantation
We assayed helper T-lymphocyte precursor frequencies (HTLPf), interferon (IFN)-γ-producing cell frequencies (IFN-γPf) and CTL precursor frequencies (CTLPf) to see if they could predict the severity of acute graft...
