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Article
Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis
Recent developments in sequencing technologies led to the discovery of a novel form of genomic instability, termed chromothripsis. This catastrophic genomic event, involved in tumorigenesis, is characterized b...
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Article
Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells
Synovial sarcoma accounts for almost 10% of all soft tissue sarcomas, and its prognosis is poor with 5-year survival rates at 36%. Thus, new treatments and therapeutic targets for synovial sarcoma are required...
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Article
Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial
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Article
High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML
EVI1 and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations are known in small subsets of leukemia. From gene expression profiling data of 130 Japanese pediatric acute myeloid ...
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Article
Open AccessPrognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group
CCAAT/enhancer-binding protein alpha (CEBPA) mutations are a favorable prognostic factor in adult acute myeloid leukemia (AML) patients; however, few studies have examined their significance in pediatric AML pati...
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Article
Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children
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Article
Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway
In the develo** vertebrate nervous system, multipotent neural stem cells produce both neurons and glia. OLIG2 is a basic helix–loop–helix transcription factor that plays critical roles in oligodendrocyte and...
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Article
Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid
Recent studies have indicated that there are many barriers to successful systemic gene delivery via cationic lipid vectors using the intravenous route. The purpose of this study was to investigate the effect o...
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Article
Adsorption and pharmacokinetics of cyclosporin A in relation to mode of infusion in bone marrow transplant patients
Two main factors that affect the pharmacokinetics of cyclosporin A (CsA) during 24-h durable intravenous (DIV) administration have been reported, namely physiological changes after bone marrow transplantation,...
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Article
Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines
Based on our earlier data on the enhancing effect of histamine on the action of interleukin-6 (IL-6), we have studied the molecular mechanisms of these interactions. The effect of histamine was investigated on...
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Chapter
Interleukin 6 (IL-6) and Its Receptor (IL-6R) in Myeloma/Plasmacytoma
Interleukin 6 (IL-6) was originally identified as a B cell differentiation factor (BCDF/BSF2) which induces final maturation of B cells into antibody producing cells (Hirano et al 1986). However, subsequent studi...
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Chapter and Conference Paper
Interleukin 6 and Its Receptor in Immune Regulation
Several factors have been shown to be involved in the regulation of B cell responses into antibody producing cells. The cDNAs for three interleukins, IL-4, IL-5 and IL-6, have been molecularly cloned and funct...
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Chapter
Regulation of human B lymphocytes differentiation: Characterization of B cell stimulatory factors
B lymphocytes originate from pluripotent hematopoietic stem cells and differentiate into antibody producing cells through several distinct differentiation stages. Commitment of the antigen specificity in each ...
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Chapter
Regulation of growth and differentiation of human B cells
Activation process of B lymphocytes into immunoglobulin (Ig)-secreting cells can be dissected into three steps, i.e., activation, proliferation and differentiation (1–3). It has been demonstrated by several in...
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Article
Four sanfilippo C patients in a family pedigree
The deficiency of acetyl-CoA:α-glucosaminideN-acetyltransferase was detected in skin fibroblast homogenates from four patients in a family pedigree. Further, it was observed that the relative proportion of the ac...
