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Article
Adsorption and pharmacokinetics of cyclosporin A in relation to mode of infusion in bone marrow transplant patients
Two main factors that affect the pharmacokinetics of cyclosporin A (CsA) during 24-h durable intravenous (DIV) administration have been reported, namely physiological changes after bone marrow transplantation,...
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Article
Preferential inhibition of CYP1A enzymes in hepatic microsomes by mexiletine
We examined the inhibitory behavior of theophylline oxidations and a variety of cytochrome P450 (P450)-dependent metabolism in the presence of mexiletine (MEX), using hepatic microsomes from both control mice ...
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Article
Relationship between erythrocyte-to-plasma distribution ratio of cyclosporin and lymphocyte proliferation in renal transplant patients
Objective: The aim of this study was to examine the relationship between erythrocyte-to-plasma distribution ratio of cyclosporin (CsA-EP) and lymphocyte proliferation as an indicator of ...
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Article
Blood-to-plasma distribution of cyclosporin A in a renal transplant recipient