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Article
A Simplified Method of Calculating an Overall Goodness-of-Fit Test for the Cox Proportional Hazards Model
Gronnesby and Borgan (1996) propose an overall goodness-of-fit test for the Cox proportional hazards model. The basis of their test is a grou** of subjects by their estimated risk score. We show that the Gro...
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Article
31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients
Most research with 31P-magnetic resonance spectroscopy (31P-MRS) in affective disorders has been done in the field of bipolar disturbances. Reduced frontal and temporal lobe phosphomonoester (PME) concentrations...
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Article
A Cautionary Note on the Use of the Grønnesby and Borgan Goodness-of-Fit Test for the Cox Proportional Hazards Model
Grønnesby and Borgan (1996, Lifetime Data Analysis 2, 315–328) propose an omnibus goodness-of-fit test for the Cox proportional hazards model. The test is based on grou** the subjects by their estimated risk sc...
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Open AccessEuroQol (EQ-5D) measure of quality of life predicts mortality, emergency department utilization, and hospital discharge rates in HIV-infected adults under care
Health-related quality of life (HR-QOL) is a relevant and quantifiable outcome of care. We implemented HR-QOL assessment at all primary care visits at UCSD Owen Clinic using EQ-5D. The study aim was to estimat...
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Meeting Practical Challenges of a Trial Involving a Multitude of Treatment Regimens: An Example of a Multi-Center Randomized Controlled Clinical Trial in NeuroAIDS
Many clinical trials compare one specific treatment to a control or standard treatment. In HIV therapeutics, such fixed-regimen designs may be problematic as individualized treatment regimens are standard prac...
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Open AccessPredictive validity of a brief antiretroviral adherence index: Retrospective cohort analysis under conditions of repetitive administration
Newer antiretroviral (ARV) agents have improved pharmacokinetics, potency, and tolerability and have enabled the design of regimens with improved virologic outcomes. Successful antiretroviral therapy is depend...
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HIV Seroprevalence, Associated Risk Behavior, and Alcohol Use Among Male Rwanda Defense Forces Military Personnel
A cross-sectional study was conducted among active-duty male soldiers, aged ≥21 years, in the Rwanda Defense Forces (RDF) and included an anonymous behavioral survey and HIV rapid testing to determine risk fac...
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Article
Performance of goodness-of-fit tests for the Cox proportional hazards model with time-varying covariates
There are few readily-implemented tests for goodness-of-fit for the Cox proportional hazards model with time-varying covariates. Through simulations, we assess the power of tests by Cox (J R Stat Soc B (Method...
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Article
On estimation of covariate-specific residual time quantiles under the proportional hazards model
Estimation and inference in time-to-event analysis typically focus on hazard functions and their ratios under the Cox proportional hazards model. These hazard functions, while popular in the statistical litera...
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Article
Open AccessMalawian children with fast-breathing pneumonia with and without comorbidities
Due to high risk of mortality, children with comorbidities are typically excluded from trials evaluating pneumonia treatment. Understanding heterogeneity of outcomes among children with pneumonia and comorbidi...
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Open AccessSerial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan
Lung ultrasound (LUS) is a promising point-of-care imaging technology for diagnosing and managing pneumonia. We sought to explore serial LUS examinations in children with chest-indrawing pneumonia in resource-...
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Open AccessAdherence to oral amoxicillin dispersible tablets in children with community-acquired pneumonia enrolled in clinical trials in Malawi
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Open AccessChest radiography in children aged 2–59 months enrolled in the Innovative Treatments in Pneumonia (ITIP) project in Lilongwe Malawi: a secondary analysis
Pneumonia is the leading infectious cause of death in children aged under 5 years in low- and middle-income countries (LMICs). World Health Organization (WHO) pneumonia diagnosis guidelines rely on non-specifi...
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Open AccessAnalysis of serious adverse events in a pediatric community-acquired pneumonia randomized clinical trial in Malawi
Amoxicillin is recommended as first-line antibiotic treatment for community-acquired pneumonia, the leading infectious cause of mortality in children aged less than 5 years. We conducted a double-blind, random...
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Open AccessA survey of barriers and facilitators to ultrasound use in low- and middle-income countries
Point-of-care ultrasound has the potential to help inform assessment, diagnosis, and management of illness in low- and middle-income countries (LMIC). To better understand current ultrasound use, barriers and ...
