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Open AccessEpigenetic signature of very low birth weight in young adult life
Globally, one in ten babies is born preterm (<37 weeks), and 1–2% preterm at very low birth weight (VLBW, <1500 g). As adults, they are at increased risk for a plethora of health conditions, e.g., cardiometabo...
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Article
Open AccessLow-grade inflammation from prenatal period to age 6–8 years in a Vitamin D trial
Low-grade systemic inflammation measured as high sensitivity C-reactive protein (hs-CRP) has been associated with non-communicable disease risk. We assessed whether prenatal inflammation and early-childhood vi...
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Article
Open AccessBody composition in adults born preterm with very low birth weight
Studies on body composition in preterm very low birth weight (VLBW < 1500 g) survivors are inconsistent and trajectories later in life unknown. We assessed body composition and its change from young to mid-adu...
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Open AccessPrenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy
Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopatholo...
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Article
Open AccessTransplantation of maternal intestinal flora to the newborn after elective cesarean section (SECFLOR): study protocol for a double blinded randomized controlled trial
A complication of elective cesarean section (CS) delivery is its interference with the normal intestinal colonization of the infant, affecting the immune and metabolic signaling in early life— a process that h...
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Open AccessCorrection to: Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants
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Open AccessCaffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants
Caffeine is widely used in preterm infants for apnea control. It has no effect on sleep in the only existing polysomnographic study including ten preterm infants Behavioral and polygraphic studies have conflic...
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Article
Open AccessNeutrophil gelatinase-associated lipocalin does not originate from the kidney during reperfusion in clinical renal transplantation
Acute Kidney Injury (AKI) is a common clinical complication. Plasma/serum neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as a rapid marker of AKI. However, NGAL is not kidney-specific. It ...
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Open AccessIntrapartal cardiotocographic patterns and hypoxia-related perinatal outcomes in pregnancies complicated by gestational diabetes mellitus
In previous reports, cardiotocographic (CTG) fetal heart rate (FHR) monitoring has shown only limited benefits in decreasing adverse perinatal outcomes in pregnancies complicated by gestational diabetes mellit...
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Open AccessEarly oxygen levels contribute to brain injury in extremely preterm infants
Extremely low gestational age newborns (ELGANs) are at risk of neurodevelopmental impairments that may originate in early NICU care. We hypothesized that early oxygen saturations (SpO2), arterial pO2 levels, and ...
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Article
Open AccessMacronutrient intake during pregnancy in women with a history of obesity or gestational diabetes and offspring adiposity at 5 years of age
The impact of maternal macronutrient intake during pregnancy on offspring childhood adiposity is unclear. We assessed the associations between maternal macronutrient intake during and after pregnancy with offs...
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Article
Spontaneous and apnea arousals from sleep in preterm infants
The significance of arousal in apnea termination in preterm infants is not known.
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Glucocorticoids, sodium transport mediators, and respiratory distress syndrome in preterm infants
Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediat...
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Article
α1,3-Fucosyltransferase-IX, an enzyme of pulmonary endogenous lung stem cell marker SSEA-1, alleviates experimental bronchopulmonary dysplasia
Endogenous pulmonary stem cells (PSCs) play an important role in lung development and repair; however, little is known about their role in bronchopulmonary dysplasia (BPD). We hypothesize that an endogenous PS...
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Open AccessMaternal pre-pregnancy overweight and gestational diabetes and dietary intakes among young adult offspring
Maternal pre-pregnancy overweight/obesity and gestational diabetes (GDM) are associated with increased fat deposition in adult offspring. The purpose of this study was to identify if maternal pre-pregnancy ove...
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Article
Open AccessThe origin of plasma neutrophil gelatinase-associated lipocalin in cardiac surgery
Acute kidney injury (AKI) is common after heart surgery. Neutrophil gelatinase-associated lipocalin (NGAL) is produced in injured kidney. NGAL has been used as an early plasma biomarker for AKI in patients und...
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Article
Effect of a lifestyle intervention during pregnancy—findings from the Finnish gestational diabetes prevention trial (RADIEL)
To assess the effect of lifestyle counseling on perinatal outcomes among women at high risk for gestational diabetes.
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Article
Open AccessThe epigenetic clock and pubertal, neuroendocrine, psychiatric, and cognitive outcomes in adolescents
Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Ye...
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Article
Season, dietary factors, and physical activity modify 25-hydroxyvitamin D concentration during pregnancy
The objectives of this cross-sectional study were to define maternal and umbilical cord blood (UCB) 25-hydroxyvitamin D (25(OH)D) to characterize maternal factors modifying 25(OH)D during pregnancy and predict...
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Article
Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women
Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in t...
