21 Result(s)
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Marius Lahti-Pulkkinen
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Article
Open AccessSex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis
Biological sex is a key variable influencing many physiological systems. Disease prevalence as well as treatment success can be modified by sex. Differences emerge already early in life and include pregnancy c...
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Open AccessAssociations of polymetabolic risk of high maternal pre-pregnancy body mass index with pregnancy complications, birth outcomes, and early childhood neurodevelopment: findings from two pregnancy cohorts
A substantial proportion of maternal pregnancy complications, adverse birth outcomes and neurodevelopmental delay in children may be attributable to high maternal pre-pregnancy Body Mass Index (BMI). However, ...
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Open AccessMaternal exposure to childhood maltreatment and mental and behavioral disorders in children
Exposure to maltreatment in childhood is associated with lifelong risk of mental and behavioral disorders. Whether the effects extend to the next generation remains unclear. We examined whether maternal exposu...
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Open AccessADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study
This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal com...
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Open AccessPrenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy
Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopatholo...
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Open AccessMaternal early-pregnancy body mass index-associated metabolomic component and mental and behavioral disorders in children
Maternal pre-pregnancy obesity and/or higher body mass index (BMI) have been associated with neurodevelopmental and mental health adversities in children. While maternal metabolomic perturbations during pregna...
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Article
Open AccessReliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies
The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates ...
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Open AccessMaternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children
Preterm birth has been linked with postpartum depressive (PPD) disorders and high symptom levels, but evidence remains conflicting and limited in quality. It remains unclear whether PPD symptoms of mothers wit...
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Open AccessMaternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland
Maternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined lo...
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Open AccessMaternal Hypertensive Pregnancy Disorders and Mental and Behavioral Disorders in the Offspring: a Review
We review here recent original research and meta-analytic evidence on the associations of maternal hypertensive pregnancy disorders and mental and behavioral disorders in the offspring.
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Article
Open AccessCharacteristics of epigenetic aging across gestational and perinatal tissues
Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especia...
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Open AccessConsequences of being overweight or obese during pregnancy on diabetes in the offspring: a record linkage study in Aberdeen, Scotland
Maternal obesity in pregnancy is associated with cardiovascular disease and mortality rate in the offspring. We aimed to determine whether maternal obesity is also associated with increased incidence of type 2...
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Open AccessIntegrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated eithe...
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Article
Open AccessInfant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood
Whether infant regulatory behavior problems already in the first month of life indicate an increased risk of childhood neurobehavioral problems, and whether maternal depression in the postpartum and early chil...
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Article
Open AccessThe Impact of Early Life Stress on Anxiety Symptoms in Late Adulthood
Early life stress (ELS) may increase the risk of anxiety throughout the life course. Whether this effect extends to late adulthood is poorly known. In our study comprising 1872 participants from the Helsinki B...
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Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review
Maternal depression complicates a large proportion of pregnancies. Current evidence shows numerous harmful effects on the offspring. Reviews, which include depression, concluded that stress has harmful effects...
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Article
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and charact...
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Article
Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight and obesity: findings from the prospective PREDO Study
Maternal overweight/obesity and comorbid hypertensive disorders and gestational diabetes associate with neurodevelopmental delay in the offspring in childhood. We hypothesize that these maternal conditions ass...
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Article
Open AccessThe epigenetic clock and pubertal, neuroendocrine, psychiatric, and cognitive outcomes in adolescents
Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Ye...
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Maternal early pregnancy obesity and related pregnancy and pre-pregnancy disorders: associations with child developmental milestones in the prospective PREDO Study
Previous studies have linked maternal pre-pregnancy obesity (BMI ≥30 kg/m2) with suboptimal neurodevelopment in her offspring; however, the literature is not entirely consistent. Whether these effects are muddled...
