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Chapter
The Role of the Brain in Prehypertension
Prolonged blood pressure (BP) elevation causes changes in the structure and function of cardiovascular organs. Therefore, our research group focused on young patients with prehypertension.
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Chapter
History of Prehypertension: Past and Present, a Saga of Misunderstanding and Neglect
Prehypertension is defined as borderline blood pressure levels that do not fall in the range defined as hypertension. Since the definition of hypertension has changed over the years, the definition of prehyper...
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Chapter
Phenotypic Changes in the Transition from Prehypertension to Established Hypertension
One third of patients with prehypertension have hyperkinetic circulation characterized by tachycardia and increased cardiac output. The hyperkinetic circulation is a predictor of future established hypertensio...
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Chapter
Prehypertension: Definitions, Clinical Significance and Therapeutic Approaches—To Treat or not to Treat?
Because of its large prevalence and association with higher cardiovascular (CV) risk, prehypertension negatively affects public health. Prehypertension starts as a minor blood pressure (BP) elevation in childh...
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Article
Establishing Targets for Hypertension Control in Patients with Comorbidities
Most current guidelines recommend tighter blood pressure (BP) control in hypertensive patients with comorbidities. These recommendations are based on epidemiologic data indicating that cardiovascular risk incr...
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Article
The role of cardiac autonomic function in hypertension and cardiovascular disease
Autonomic nervous system abnormality, clinically manifested as a hyperkinetic circulation characterized by elevations in heart rate, blood pressure, plasma norepinephrine levels, and cardiac output, has been r...
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Article
The Short Treatment with the Angiotensin Receptor Blocker Candesartan Surveyed by Telemedicine (STAR CAST) Study: Rationale and Study Design
Previous studies have shown that transient treatment of animal models of hypertension with an angiotensin receptor blocker (ARB) causes a sustained decrease in blood pressure values that persists even after th...
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Article
Prehypertension: Risk stratification and management considerations
Approximately 37% of US adults are prehypertensive; about 31 million have blood pressures in the range of 130–139/85–89 mm Hg. These stage 2 prehypertensives have threefold greater risk for develo** hyperten...
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Article
Impact of Increased Heart Rate on Clinical Outcomes in Hypertension
Thirty-eight studies have been published to date on the association between elevated heart rate and mortality. After adjustment for other risk factors, only two studies for all-cause mortality and four studies...
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Article
Clinical Experience with Perindopril in Elderly Hypertensive Patients
To evaluate the effectiveness and safety of perindopril in a subgroup of 3010 elderly (≥65 years) hypertensive patients, who participated in a large US general practice-based community trial.
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Chapter
Role of the Nervous System in Human Hypertension
Despite early demonstrations that sympathetic activation elevates blood pressure and early clinical inklings that human hypertension may have a psychosomatic component, the pivotal role of the nervous system i...
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Chapter
Role of the Nervous System in Human Hypertension
Despite early demonstrations that sympathetic activation elevates blood pressure and early clinical inklings that human hypertension may have a psychosomatic component, the pivotal role of the nervous system i...
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Chapter
Hemodynamic Assessment and Pharmacologic Probes as Tools to Analyze Cardiovascular Reactivity
The blood pressure and heart rate responses to a laboratory task are most frequently used to assess an individual’s cardiovascular reactivity. Information from such observation is useful for general categoriza...
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Chapter
The hemodynamics of borderline hypertension
The hemodynamic history of borderline hypertension is rich with the contributions of numerous investigators over the past five decades. This is a particularly propitious time to review the literature, since it...
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Chapter
Assessment Of Autonomic Function in Essential Hypertension
Assessment of the sympathetic tone in humans traditionally involves measurement of plasma norepinephrine (NE). Other biochemical approaches, such as measurement of dopamine beta-hydroxylase (DBH) have also bee...
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Chapter
Controversies in the Research on Hemodynamic Mechanisms in the Development of Hypertension
Regardless of the underlying cause or causes, a permanent elevation of blood pressure must, by definition, represent a derangement of homeostatic mechanisms that under ordinary conditions maintain normotension...
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Chapter
Therapeutic decisons in management of borderline hypertension
In this chapter the thesis will be developed that for patients with very mild hypertension, antihypertensive therapy is not mandatory, but some of these patients are heading for trouble and it would be useful ...
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Chapter
Psychophysiologic Evidence for the Role of the Nervous System in Hypertension
As early as 1905, the same year that Korotkoff described a practical method for measurement of the diastolic blood pressure, Geisböck[1], using the old method of finger occlusion plethysmography, stated that a...
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Article
Reliability of echocardiography in assessing cardiac output
Because of the potential benefits from a noninvasive technique in assessing cardiac output, we compared cardiac output estimates from left ventricular echocardiograms with results obtained simultaneously by a ...
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Chapter and Conference Paper
Borderline Hypertension: Clinical and Pathophysiologic Significance
Borderline hypertension can best be characterized as a condition where a subject’s blood pressure is above the normal range, but is not sufficiently elevated to warrant immediate treatment. This “gray zone” be...
