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    Facile target validation in an animal model with intracellularly expressed monobodies

    Rapidly determining the biological effect of perturbing a site within a potential drug target could guide drug discovery efforts, but it remains challenging. Here, we describe a facile target validation approa...

    Ankit Gupta, **g Xu, Shirley Lee, Steven T. Tsai, Bo Zhou… in Nature Chemical Biology (2018)