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Bioprocess Monitoring Using Near-Infrared Spectroscopy
Near-infrared spectroscopy (NIR) is a nondestructive analytical technique that has been used for simultaneous prediction of the concentrations of...
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Metabolic Flux Analysis Based on 13C-Labeling Experiments and Integration of the Information with Gene and Protein Expression Patterns
The recent progress on metabolic systems engineering was reviewed, in particular focusing on the metabolic flux analysis (MFA) based on the...
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Biochemical Reaction Engineering and Process Development in Anaerobic Wastewater Treatment
Developments in production technology have frequently resulted in the concentrated local accumulation of highly organic-laden wastewaters. Anaerobic...
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Applying Metabolic Profiling Techniques for Stimulus-Response Experiments: Chances and Pitfalls
So far it is mainly transcriptome and proteome analysis that has been applied to elucidate the correlation between genotype and phenotype although...
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Recent Progress in Microbial Cultivation Techniques
Recent advances in the improvement of microbial cultivation are reviewed, with emphasis on biochemical engineering techniques as a means of obtaining...
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Transgenic Birds for the Production of Recombinant Proteins
Transgenic birds were expected to be an excellent transgenic bioreactor for the production of recombinant pharmaceutical proteins. However, the only...
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High Rate Production of Hydrogen/Methane from Various Substrates and Wastes
To treat soluble and solid wastes and recover energy from them, high rate methane fermentation, especially using the UASB (upflow anaerobic sludge...
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Cell-free Protein Synthesis Systems: Increasing their Performance and Applications
The Escherichia coli cell-free protein synthesis system can now be used for various proteins that need special requirements, such as disulfide bond...
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Application of Knowledge Information Processing Methods to Biochemical Engineering, Biomedical and Bioinformatics Fields
In biochemical and biomedical engineering fields there are a variety of phenomena with many complex chemical reactions, in which many genes and...
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Cofactor Regeneration at the Lab Scale
Progress made in lab-scale applications of various coenzyme regeneration systems over the last two decades has mainly focused on the applications of...
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From Stationary to Instationary Metabolic Flux Analysis
Metabolic flux analysis using 13C labeled substrates is an important tool for metabolic engineering. Although it has now been evolving for more than...
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Biochemical Engineering Aspects of Expanded Bed Adsorption
The economic feasibility of a biotechnological production process is directly linked to the number and efficiency of the processes required during...
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Parallel Reactor Systems for Bioprocess Development
Controlled parallel bioreactor systems allow fed-batch operation at early stages of process development. The characteristics of shaken bioreactors...
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Large-Scale Micropropagation System of Plant Cells
Plant micropropagation is an efficient method of propagating disease-free, genetically uniform and massive amounts of plants in vitro. The scale-up...
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Clarification of Interactions among Microorganisms and Development of Co-culture System for Production of Useful Substances
Co-culture systems containing two microorganisms for the production of useful substances are described. We developed a novel co-culture system...
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Bacterial Capsular Polysaccharide and Sugar Transferases
Capsular polysaccharides (CPs) of several pathogenic bacteria are thought to be good materials for the development of new therapeutic reagents. These...
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Development of Culture Techniques of Keratinocytes for Skin Graft Production
The in vitro cultures of human tissues have attracted a great deal of medical attention as a promising technique for repairing defective tissues in...
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The Oxygen Mass Transfer, Carbon Dioxide Inhibition, Heat Removal, and the Energy and Cost Efficiencies of High Pressure Fermentation
This study focuses on the enhancement of oxygen transfer in aerobic fermentation processes through the use of the reactor headspace pressure as a...
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Membrane Reactors at Degussa
The review covers the development of membrane reactor technologies at Degussa for the synthesis of fine chemicals. The operation of fed-batch or...
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Bacterial Sterilization and Intracellular Protein Release by a Pulsed Electric Field
Several biotechnological applications of high-voltage pulsed electric field (PEF) are introduced. Electrical breakdown or disruption of a biological...