Skip to main content

2 Result(s)

within Steven T. Tsai Remove this filter

and

  1. Article

    Open Access

    Selective and noncovalent targeting of RAS mutants for inhibition and degradation

    Activating mutants of RAS are commonly found in human cancers, but to date selective targeting of RAS in the clinic has been limited to KRAS(G12C) through covalent inhibitors. Here, we report a monobody, termed 1...

    Kai Wen Teng, Steven T. Tsai, Takamitsu Hattori, Carmine Fedele… in Nature Communications (2021)

    Download PDF (2843 KB) View Article

  2. No Access

    Article

    Facile target validation in an animal model with intracellularly expressed monobodies

    Rapidly determining the biological effect of perturbing a site within a potential drug target could guide drug discovery efforts, but it remains challenging. Here, we describe a facile target validation approa...

    Ankit Gupta, **g Xu, Shirley Lee, Steven T. Tsai, Bo Zhou… in Nature Chemical Biology (2018)