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Open AccessMedico-legal issues related to emergency physicians’ documentation in Canadian emergency departments
Physician documentation plays a central role in the delivery of safe patient care. It describes a physician’s clinical decision-making and supports essential communication between healthcare providers within t...
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Navigating gaps in practice: consensus recommendations for educational and support structures for emergency physicians returning from gaps in practice
The purpose of this study was to identify the learning needs of emergency physicians returning to Emergency Medicine (EM) practice after clinical leaves of less than 2 years, summarize existing return to pract...
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Facile target validation in an animal model with intracellularly expressed monobodies
Rapidly determining the biological effect of perturbing a site within a potential drug target could guide drug discovery efforts, but it remains challenging. Here, we describe a facile target validation approa...
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Open AccessTranscriptional regulation of Annexin A2 promotes starvation-induced autophagy
Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway m...
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Sediment quality guidelines: challenges and opportunities for improving sediment management
During the International Conference on Deriving Environmental Quality Standards for the Protection of Aquatic Ecosystems held in Hong Kong in December 2011, an expert group, comprising scientists, government o...
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Open AccessTherapeutic induction of autophagy to modulate neurodegenerative disease progression
There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review,...
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Reference Work Entry In depth
Systemic Lupus Erythematosus
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Article
Health and Sickness: The Meaning of Menstruation and Premenstrual Syndrome in Women's Lives
The experience of menstruation was examined through an analysis of women's narratives in order to understand perceptions of menstrual cycle changes. Research within a medical anthropology perspective was condu...
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Article
Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5
Human macrophages can be infected more efficiently by M-tropic than by T-tropic HIV-1 strains, despite surface expression of both CXCR4 and CCR5 co-receptors. Western blot analyses of total cell extracts and s...
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Article
Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: Implications for HIV primary infection
Transmission of HIV-1 is predominantly restricted to macrophage (MΦ)-tropic strains. Langerhans ceils (LCs) in mucosal epithelium, as well as macrophages located in the submucosal tissues, may be initial targe...
