7 Result(s)
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Article
Open AccessPGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
Cardiomyocytes undergo significant structural and functional changes after birth, and these fundamental processes are essential for the heart to pump blood to the growing body. However, due to the challenges o...
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Article
Open AccessBiomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread
The root cause of cancer mortality and morbidity is the metastatic spread of the primary tumor, but underlying mechanisms remain elusive. Here we investigate biomechanical interactions that may accompany invas...
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Article
Open AccessTGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness
Here we report exquisitely distinct material properties of primary vascular smooth muscle (VSM) cells isolated from the thoracic aorta of adult (8 months) vs. aged (30 months) F344XBN rats. Individual VSM cells d...
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Article
Open AccessAIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination
A defining hallmark of primary and metastatic cancers is the migration and invasion of malignant cells. These invasive properties involve altered dynamics of the cytoskeleton and one of its major structural co...
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Open AccessRole of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone
The present study focused on the role of microRNA-139-5p (miRNA-139-5p) in the regulation of basal tone in internal anal sphincter (IAS). Applying genome-wide miRNA microarrays on the phenotypically distinct s...
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Article
Open AccessDefining an olfactory receptor function in airway smooth muscle cells
Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM) mass and cellular remodeling that occur in asthma are not well defined. Here we report the expression of odorant ...
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Article
Universal physical responses to stretch in the living cell
How do cells in our body go about their routine mechanical business of stretching, contracting and remodelling? This question has far-reaching implications for understanding airway narrowing in asthma, cell in...
