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Article
Open AccessCompression enhances invasive phenotype and matrix degradation of breast cancer cells via Piezo1 activation
Uncontrolled growth in solid breast cancer generates mechanical compression that may drive the cancer cells into a more invasive phenotype, but little is known about how such compression affects the key events...
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Article
Effects of the Lower Airway Secretions on Airway Opening Pressures and Suction Pressures in Critically Ill COVID-19 Patients: A Computational Simulation
In patients with critically ill COVID-19 pneumonia, lower airways are filled with plenty of highly viscous exudates or mucus, leading to airway occlusion. The estimation of airway opening pressures and effecti...
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Article
Reproducibility and Radiation Effect of High-Resolution In Vivo Micro Computed Tomography Imaging of the Mouse Lumbar Vertebra and Long Bone
A moderate radiation dose, in vivo µCT scanning protocol was developed and validated for long-term monitoring of multiple skeletal sites (femur, tibia, vertebra) in mice. A customized, 3D printed mouse holder was...
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Article
Open AccessDetermination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques
By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also co...
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Article
Open AccessA novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models
A disintegrin and metalloproteinase 8 (ADAM8) has been identified as a signature gene associated with moderate and severe asthma. Studies in mice have demonstrated that the severity of asthma can be reduced by...
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Article
Toothpaste microstructure and rheological behaviors including aging and partial rejuvenation
Toothpastes are mainly composed of a dense suspension of abrasive substances, flavors, and therapeutic ingredients in a background liquid of humectants and water, and usually exhibit complex rheological behavi...
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Article
Distinctive pharmacological differences between liver cancer cell lines HepG2 and Hep3B
As cellular models for in vitro liver cancer and toxicity studies, HepG2 and Hep3B are the two most frequently used liver cancer cell lines. Because of their similarities they are often treated as the same in ...
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Article
Depletion effect and biomembrane budding
Depletion effects are well known to lead to phase separation in microsystems consisting of large and small particles with short-range repulsive interactions that act over macromolecular length scales. The equi...
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Article
Open AccessIn vitro assay of cytoskeleton nanomechanics as a tool for screening potential anticancer effects of natural plant extract, tubeimoside I on human hepatoma (HepG2) cells
Cytoskeleton nanomechanics characterizes cancer cell’s physical behaviors such as how it spread and invade. For anticancer drug, cytoskeleton nanomechanics may be a target to inhibit invasiveness and metastasi...
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Article
Upregulation of SDF-1 is Associated with Atherosclerosis Lesions Induced by LDL Concentration Polarization
Previous numerical simulations on low-density lipoprotein (LDL) concentration polarization in the arterial system indicated that LDL concentration polarization might play an important role in the genesis and d...
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Article
Evaluation of Accuracy for the Measurement of Octanol–Water Partition Coefficient by MEEKC
Microemulsion electrokinetic chromatography (MEEKC) has been widely used as an indirect tool to measure octanol–water partition coefficients (logP ow) of various kinds of compounds. In this paper,...
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Article
Open AccessEvaluating interaction forces between BSA and rabbit anti-BSA in sulphathiazole sodium, tylosin and levofloxacin solution by AFM
Protein-protein interactions play crucial roles in numerous biological processes. However, it is still challenging to evaluate the protein-protein interactions, such as antigen and antibody, in the presence of...
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Article
Imaging and determining friction forces of specific interactions between human IgG and rat anti-human IgG
Covalently immobilized rat anti-human immunoglobulin (IgG) monolayers on thiol-modified gold substrates and human IgG linked with the tips were fabricated using the self-assembled monolayer method, and interac...
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Article
Stepwise Increasing and Decreasing Fluid Shear Stresses Differentially Regulate the Functions of Osteoblasts
It is well accepted that osteoblasts respond to fluid shear stress (FSS) depending on the loading magnitude, rate, and temporal profiles. Although in vivo observations demonstrated that bone mineral density chang...
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Article
Open AccessProbing Specific Interaction Forces Between Human IgG and Rat Anti-Human IgG by Self-Assembled Monolayer and Atomic Force Microscopy
Interaction forces between biological molecules such as antigen and antibody play important roles in many biological processes, but probing these forces remains technically challenging. Here, we investigated t...
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Article
Open AccessPreparation and Characterization of Covalently Binding of Rat Anti-human IgG Monolayer on Thiol-Modified Gold Surface
The 16-mercaptohexadecanoic acid (MHA) film and rat anti-human IgG protein monolayer were fabricated on gold substrates using self-assembled monolayer (SAM) method. The surface properties of the bare gold subs...
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Article
Sulfoalkyl ether β-cyclodextrin derivatives synthesized by a single step method as pharmaceutical biomaterials
We report a simple “one pot” single step method to synthesize sulfoalkyl ether β-cyclodextrin (β-CD) derivatives in aqueous solution, which avoids the limitations associated with commonly used organic synthesi...
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Article
Universal physical responses to stretch in the living cell
How do cells in our body go about their routine mechanical business of stretching, contracting and remodelling? This question has far-reaching implications for understanding airway narrowing in asthma, cell in...
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Article
Fast and slow dynamics of the cytoskeleton
Material moduli of the cytoskeleton (CSK) influence a wide range of cell functions1,2,3. There is substantial evidence from reconstituted F-actin gels that a regime exists in which the moduli scale with frequency...
