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Brain health in preterm infants: importance of early-life pain and analgesia exposure
“Everyday” exposures in the neonatal period, such as pain, may impact brain health in preterm infants. Specifically, greater exposure to painful procedures in the initial weeks after birth have been related to...
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Open AccessMaternal milk in the NICU: An everyday intervention to improve brain development
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Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants
We assessed variability of analgesic use across three tertiary neonatal intensive care units (NICUs) accounting for early-life pain, quantified as number of invasive procedures. We also determined whether anal...
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Training in neonatal neurocritical care: a proposal for a hybrid model of competence by design and time-based methods
Neonatal neurocritical care (NNCC) is a rapidly advancing field with limited fellowship training available in locally developed, non-accredited programs. A standardized survey aimed to understand the training ...
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Longitudinal neurodevelopmental outcomes in preterm twins
Several factors contribute to neurodevelopmental outcomes in preterm infants. The aim of this study was to examine the genetic and environmental influences on long-term outcomes in preterm twins.
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Early EEG in neonates with mild hypoxic–ischemic encephalopathy: more than meets the eye
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The influence of pain, agitation, and their management on the immature brain
Preterm infants are exposed to frequent painful procedures and agitating stimuli over the many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse neurobiological impact of p...
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Socioeconomic status and brain injury in children born preterm: modifying neurodevelopmental outcome
Improved intensive care therapies have increased the survival of children born preterm. Yet, many preterm children experience long-term neurodevelopmental sequelae. Indeed, preterm birth remains a leading caus...
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Plasma cholesterol levels and brain development in preterm newborns
To assess whether postnatal plasma cholesterol levels are associated with microstructural and macrostructural regional brain development in preterm newborns.
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Commentary on “The long-term effect of perinatal asphyxia on hippocampal volumes”
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Brain abnormalities in children and adolescents with chronic kidney disease
Chronic kidney disease (CKD) is a risk factor for vascular disease and stroke. The spectrum of brain injury and microstructural white matter abnormalities in children with CKD is largely unknown.
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Postnatal polyunsaturated fatty acids associated with larger preterm brain tissue volumes and better outcomes
Human studies investigating the link between postnatal polyunsaturated fatty acids and preterm brain growth are limited, despite emerging evidence of potential effects on outcomes.
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Early postnatal docosahexaenoic acid levels and improved preterm brain development
Preterm birth has a dramatic impact on polyunsaturated fatty acid exposures for the develo** brain. This study examined the association between postnatal fatty acid levels and measures of brain injury and de...
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Society for Pediatric Research 2014 Presidential Address: the test of our progress
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Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic–ischemic encephalopathy
Brain injury in term neonatal hypoxic–ischemic encephalopathy (HIE) emerges on magnetic resonance imaging (MRI) by day 3. This study aimed to address the relationship of MRI, diffusion tensor imaging (DTI), an...
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Single-ventricle anatomy predicts delayed microstructural brain development
Term newborns with congenital heart disease (CHD) show delayed brain development as early as the third trimester, especially in single-ventricle physiology (SVP). Mechanisms causing delayed brain development i...
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Postnatal infection is associated with widespread abnormalities of brain development in premature newborns
Infection is a risk factor for adverse neurodevelopmental outcome in preterm newborns. Our objective was to characterize the association of postnatal infection with adverse microstructural and metabolic brain ...
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Magnetoencephalography Reveals Slowing of Resting Peak Oscillatory Frequency in Children Born Very Preterm
Resting cortical activity is characterized by a distinct spectral peak in the alpha frequency range. Slowing of this oscillatory peak toward the upper theta-band has been associated with a variety of neurologi...
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Cerebellar Development in the Preterm Neonate: Effect of Supratentorial Brain Injury
Cerebellar injury has been increasingly recognized as a complication of preterm birth, with decreased cerebellar volumes seen on follow-up neuroimaging. A cohort of 38 preterm newborns, including 14 with two s...
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White Matter Injury in Term Newborns With Neonatal Encephalopathy
White matter injury (WMI) is the characteristic pattern of brain injury detected on magnetic resonance imaging in the premature newborn. Focal noncystic WMI is increasingly recognized in populations of term ne...