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Article
Open AccessMRI based radiomics enhances prediction of neurodevelopmental outcome in very preterm neonates
To predict adverse neurodevelopmental outcome of very preterm neonates. A total of 166 preterm neonates born between 24–32 weeks’ gestation underwent brain MRI early in life. Radiomics features were extracted ...
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Article
Longitudinal neurodevelopmental outcomes in preterm twins
Several factors contribute to neurodevelopmental outcomes in preterm infants. The aim of this study was to examine the genetic and environmental influences on long-term outcomes in preterm twins.
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Article
Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study
To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks’ gestation at 18–24 months of corrected age.
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Article
Open AccessA cluster randomized clinical trial to evaluate the effectiveness of the Implementation of Infant Pain Practice Change (ImPaC) Resource to improve pain practices in hospitalized infants: a study protocol
Hospitalized infants undergo multiple painful procedures daily. Despite the significant evidence, procedural pain assessment and management continues to be suboptimal. Repetitive and untreated pain at this vit...
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Article
RAPIDOMICS: rapid genome-wide sequencing in a neonatal intensive care unit—successes and challenges
Genetic disorders are one of the leading causes of infant mortality and are frequent in neonatal intensive care units (NICUs). Rapid genome-wide sequencing (GWS; whole genome or exome sequencing (ES)), due to ...
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Article
Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation: a multicenter cohort study
To compare neurodevelopmental outcomes of preterm infants at 18–21 months corrected age (CA) whose mothers smoked during pregnancy to those whose mothers did not smoke.
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Article
Open AccessThe minimally effective dose of sucrose for procedural pain relief in neonates: a randomized controlled trial
Orally administered sucrose is effective and safe in reducing pain intensity during single, tissue-damaging procedures in neonates, and is commonly recommended in neonatal pain guidelines. However, there is wi...
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Article
Postnatal polyunsaturated fatty acids associated with larger preterm brain tissue volumes and better outcomes
Human studies investigating the link between postnatal polyunsaturated fatty acids and preterm brain growth are limited, despite emerging evidence of potential effects on outcomes.
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Article
Open AccessInvasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls
This multicenter prospective study of invasive candidiasis (IC) was carried out to determine the risk factors for, incidence of, clinical and laboratory features, treatment and outcome of IC in infants of birt...
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Article
Birth Outcomes in Newborns Fathered by Men with Multiple Sclerosis Exposed to Disease-Modifying Drugs
The aim of this study was to determine the incidence of births fathered by men with multiple sclerosis (MS) exposed to a disease-modifying drug (DMD) around the time of conception, and investigate the associat...
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Article
A Review of Safety-Related Pregnancy Data Surrounding the Oral Disease-Modifying Drugs for Multiple Sclerosis
The recent approval of several oral disease-modifying drugs (DMDs) for multiple sclerosis (MS) brings promise of improved clinical effectiveness as well as greater drug compliance compared to the existing non-...
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Article
Obstetrical epidural and spinal anesthesia in multiple sclerosis
To examine obstetrical epidural and spinal anesthesia use in women with multiple sclerosis (MS) and the relationship with MS clinical factors. This was a retrospective cohort study, linking clinical data from ...
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Article
Resuscitation intensity at birth is associated with changes in brain metabolic development in preterm neonates
Intensive resuscitation at birth has been linked to intraventricular haemorrhage (IVH) in the preterm neonate. However, the impact of less intensive resuscitation on more subtle alterations in brain metabolic ...
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Article
Postnatal infection is associated with widespread abnormalities of brain development in premature newborns
Infection is a risk factor for adverse neurodevelopmental outcome in preterm newborns. Our objective was to characterize the association of postnatal infection with adverse microstructural and metabolic brain ...
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Article
Magnetoencephalography Reveals Slowing of Resting Peak Oscillatory Frequency in Children Born Very Preterm
Resting cortical activity is characterized by a distinct spectral peak in the alpha frequency range. Slowing of this oscillatory peak toward the upper theta-band has been associated with a variety of neurologi...
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Chapter
What We Learned about Early Identification and Screening
This chapter focuses on The Developmental Pathways, Infant Neuromotor, Community-Based Screening, and The Indigenous Child studies.1 We have chosen to focus on these four studies for two particular reasons. First...
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Chapter and Conference Paper
Altered Long-Range Phase Synchronization and Cortical Activation in Children Born Very Preterm
Children born very preterm, even with broadly normal IQ, commonly show selective difficulties in visuospatial processing and executive functioning. Very little, however, is known what alterations in cortical p...
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Article
Open AccessCharacteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study
There is limited information in the literature on the presentation and prognosis of candidal urinary tract infection (UTI) in infants in the neonatal intensive care unit (NICU).
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Article
Open AccessActuarial survival of a large Canadian cohort of preterm infants
The increased survival of preterm and very low birth weight infants in recent years has been well documented but continued surveillance is required in order to monitor the effects of new therapeutic interventi...
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Article
SURVIVAL AT THE BORDERLINE OF VIABILITY (22-24 WEEKS). 1484
