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Article
Brain health in preterm infants: importance of early-life pain and analgesia exposure
“Everyday” exposures in the neonatal period, such as pain, may impact brain health in preterm infants. Specifically, greater exposure to painful procedures in the initial weeks after birth have been related to...
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Article
Open AccessMaternal milk in the NICU: An everyday intervention to improve brain development
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Article
Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants
We assessed variability of analgesic use across three tertiary neonatal intensive care units (NICUs) accounting for early-life pain, quantified as number of invasive procedures. We also determined whether anal...
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Article
Open AccessMRI based radiomics enhances prediction of neurodevelopmental outcome in very preterm neonates
To predict adverse neurodevelopmental outcome of very preterm neonates. A total of 166 preterm neonates born between 24–32 weeks’ gestation underwent brain MRI early in life. Radiomics features were extracted ...
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Article
Open AccessThe Effect of Size and Asymmetry at Birth on Brain Injury and Neurodevelopmental Outcomes in Congenital Heart Disease
Poor and asymmetric fetal growth have been associated with neonatal brain injury (BI) and worse neurodevelopmental outcomes (NDO) in the growth-restricted population due to placental insufficiency. We tested t...
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Article
A kinase-cGAS cascade to synthesize a therapeutic STING activator
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this chal...
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Article
Training in neonatal neurocritical care: a proposal for a hybrid model of competence by design and time-based methods
Neonatal neurocritical care (NNCC) is a rapidly advancing field with limited fellowship training available in locally developed, non-accredited programs. A standardized survey aimed to understand the training ...
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Article
Longitudinal neurodevelopmental outcomes in preterm twins
Several factors contribute to neurodevelopmental outcomes in preterm infants. The aim of this study was to examine the genetic and environmental influences on long-term outcomes in preterm twins.
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Article
Early EEG in neonates with mild hypoxic–ischemic encephalopathy: more than meets the eye
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Article
Open AccessEarly protein intake predicts functional connectivity and neurocognition in preterm born children
Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whet...
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Article
The influence of pain, agitation, and their management on the immature brain
Preterm infants are exposed to frequent painful procedures and agitating stimuli over the many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse neurobiological impact of p...
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Article
Socioeconomic status and brain injury in children born preterm: modifying neurodevelopmental outcome
Improved intensive care therapies have increased the survival of children born preterm. Yet, many preterm children experience long-term neurodevelopmental sequelae. Indeed, preterm birth remains a leading caus...
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Article
Plasma cholesterol levels and brain development in preterm newborns
To assess whether postnatal plasma cholesterol levels are associated with microstructural and macrostructural regional brain development in preterm newborns.
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Article
Commentary on “The long-term effect of perinatal asphyxia on hippocampal volumes”
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Article
Brain abnormalities in children and adolescents with chronic kidney disease
Chronic kidney disease (CKD) is a risk factor for vascular disease and stroke. The spectrum of brain injury and microstructural white matter abnormalities in children with CKD is largely unknown.
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Article
Neonatal stroke and haematuria: Questions
This is a report of an infant born near term with neonatal stroke and haematuria. Changes were noted on foetal magnetic resonance images, and these persisted postnatally. A routine renal ultrasound scan during...
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Article
Neonatal stroke and haematuria: Answers
This is a report of an infant born near term with neonatal stroke and haematuria. The renal phenotype, pathogenic genotype and pathological findings on renal biopsy are discussed.
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Article
Postnatal polyunsaturated fatty acids associated with larger preterm brain tissue volumes and better outcomes
Human studies investigating the link between postnatal polyunsaturated fatty acids and preterm brain growth are limited, despite emerging evidence of potential effects on outcomes.
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Chapter and Conference Paper
Combining Spatial and Non-spatial Dictionary Learning for Automated Labeling of Intra-ventricular Hemorrhage in Neonatal Brain MRI
A specific challenge to accurate tissue quantification in premature neonatal MRI data is posed by Intra-Ventricular Hemorrhage (IVH), where severe cases can be accompanied by extreme and complex Ventriculomega...
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Chapter and Conference Paper
Prediction of Brain Network Age and Factors of Delayed Maturation in Very Preterm Infants
Babies born very preterm (<32 weeks postmenstral age), are at a high risk of having delayed or altered neurodevelopment. Diffusion MRI (dMRI) is a non-invasive neuroimaging modality that allows for early analy...
