-
Article
Open AccessMotion corrected MRI differentiates male and female human brain growth trajectories from mid-gestation
It is of considerable scientific, medical, and societal interest to understand the developmental origins of differences between male and female brains. Here we report the use of advances in MR imaging and anal...
-
Article
Plasma cholesterol levels and brain development in preterm newborns
To assess whether postnatal plasma cholesterol levels are associated with microstructural and macrostructural regional brain development in preterm newborns.
-
Article
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain
Zika virus infection of pregnant nonhuman primates results in the loss of fetal neuronal progenitor cells, even in the absence of overt microcephaly.
-
Article
Postnatal polyunsaturated fatty acids associated with larger preterm brain tissue volumes and better outcomes
Human studies investigating the link between postnatal polyunsaturated fatty acids and preterm brain growth are limited, despite emerging evidence of potential effects on outcomes.
-
Chapter and Conference Paper
Combining Spatial and Non-spatial Dictionary Learning for Automated Labeling of Intra-ventricular Hemorrhage in Neonatal Brain MRI
A specific challenge to accurate tissue quantification in premature neonatal MRI data is posed by Intra-Ventricular Hemorrhage (IVH), where severe cases can be accompanied by extreme and complex Ventriculomega...
-
Article
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate
New animal models of Zika virus (ZIKV) infection are imperative to accelerating efforts to treat or prevent disease in humans. Adams Waldorf et al. now report that ZIKV infection of a pregnant female pigtailed ma...
-
Article
Systemic glycerol decreases neonatal rabbit brain and cerebellar growth independent of intraventricular hemorrhage
Cerebellar hypoplasia is a common problem in preterm infants and infants suffering from intraventricular hemorrhage (IVH). To evaluate the effects of IVH on cerebellar growth and development, we used a neonata...
-
Article
Volumetric and surface-based 3D MRI analyses of fetal isolated mild ventriculomegaly
Diagnosis of fetal isolated mild ventriculomegaly (IMVM) is the most common brain abnormality on prenatal ultrasound. We have set to identify potential alterations in brain development specific to IMVM in tiss...
-
Article
3D Morphometric Analysis of Human Fetal Cerebellar Development
To date, growth of the human fetal cerebellum has been estimated primarily from linear measurements from ultrasound and 2D magnetic resonance imaging (MRI). In this study, we use 3D analytical methods to devel...
-
Article
Fetal Hippocampal Development: Analysis by Magnetic Resonance Imaging Volumetry
The hippocampal formation plays an important role in learning and memory; however, data on its development in utero in humans are limited. This study was performed to evaluate hippocampal development in healthy f...
-
Chapter and Conference Paper
Spatiotemporal Morphometry of Adjacent Tissue Layers with Application to the Study of Sulcal Formation
The process of brain growth involves the expansion of tissue at different rates at different points within the brain. As the layers within the develo** brain evolve they can thicken or increase in area as th...
-
Chapter and Conference Paper
Data-Driven Cortex Segmentation in Reconstructed Fetal MRI by Using Structural Constraints
In utero fetal MR images are essential for the diagnosis of abnormal brain development and understanding brain structures maturation. Because of particular properties of these images, such as imp...
-
Chapter and Conference Paper
Reconstruction of Scattered Data in Fetal Diffusion MRI
In this paper we present a method for reconstructing D-MRI data on regular grids from sparse data without assuming specific diffusion models. This is particularly important when studying the fetal brain in utero,...
-
Chapter and Conference Paper
Measures for Characterizing Directionality Specific Volume Changes in TBM of Brain Growth
Tensor based morphology (TBM) is a powerful approach to analyze local structural changes in brain anatomy. However, conventional scalar TBM methods are unable to present direction-specific analysis of volume c...
-
Chapter and Conference Paper
A Non-Local Fuzzy Segmentation Method: Application to Brain MRI
The Fuzzy C-Means algorithm is a widely used and flexible approach for brain tissue segmentation from 3D MRI. Despite its recent enrichment by addition of a spatial dependency to its formulation, it remains qu...
-
Chapter and Conference Paper
A Spatio-temporal Atlas of the Human Fetal Brain with Application to Tissue Segmentation
Modeling and analysis of MR images of the early develo** human brain is a challenge because of the transient nature of different tissue classes during brain growth. To address this issue, a statistical model...
-
Chapter and Conference Paper
Atlas-Based Segmentation of the Germinal Matrix from in Utero Clinical MRI of the Fetal Brain
Recently developed techniques for reconstruction of high-resolution 3D images from fetal MR scans allows us to study the morphometry of develo** brain tissues in utero. However, existing adult brain analysis...
-
Chapter and Conference Paper
Incorporating DTI Data as a Constraint in Deformation Tensor Morphometry Between T1 MR Images
Deformation tensor morphometry provides a sensitive approach to detecting and map** subtle volume changes in the brain from conventional high resolution T1W MRI data. However, it is limited in its ability to...
-
Chapter and Conference Paper
Population Based Analysis of Directional Information in Serial Deformation Tensor Morphometry
Deformation morphometry provides a sensitive approach to detecting and map** subtle volume changes in the brain. Population based analyses of this data have been used successfully to detect characteristic ch...
-
Chapter and Conference Paper
A System for Measuring Regional Surface Folding of the Neonatal Brain from MRI
This paper describes a novel approach to in-vivo measurement of brain surface folding in clinically acquired neonatal MR image data, which allows evaluation of surface curvature within subregions of the cortex...
