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Brain health in preterm infants: importance of early-life pain and analgesia exposure
“Everyday” exposures in the neonatal period, such as pain, may impact brain health in preterm infants. Specifically, greater exposure to painful procedures in the initial weeks after birth have been related to...
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Open AccessMaternal milk in the NICU: An everyday intervention to improve brain development
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Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants
We assessed variability of analgesic use across three tertiary neonatal intensive care units (NICUs) accounting for early-life pain, quantified as number of invasive procedures. We also determined whether anal...
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Open AccessThe Effect of Size and Asymmetry at Birth on Brain Injury and Neurodevelopmental Outcomes in Congenital Heart Disease
Poor and asymmetric fetal growth have been associated with neonatal brain injury (BI) and worse neurodevelopmental outcomes (NDO) in the growth-restricted population due to placental insufficiency. We tested t...
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Training in neonatal neurocritical care: a proposal for a hybrid model of competence by design and time-based methods
Neonatal neurocritical care (NNCC) is a rapidly advancing field with limited fellowship training available in locally developed, non-accredited programs. A standardized survey aimed to understand the training ...
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Longitudinal neurodevelopmental outcomes in preterm twins
Several factors contribute to neurodevelopmental outcomes in preterm infants. The aim of this study was to examine the genetic and environmental influences on long-term outcomes in preterm twins.
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Early EEG in neonates with mild hypoxic–ischemic encephalopathy: more than meets the eye
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The influence of pain, agitation, and their management on the immature brain
Preterm infants are exposed to frequent painful procedures and agitating stimuli over the many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse neurobiological impact of p...
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Socioeconomic status and brain injury in children born preterm: modifying neurodevelopmental outcome
Improved intensive care therapies have increased the survival of children born preterm. Yet, many preterm children experience long-term neurodevelopmental sequelae. Indeed, preterm birth remains a leading caus...
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Article
Plasma cholesterol levels and brain development in preterm newborns
To assess whether postnatal plasma cholesterol levels are associated with microstructural and macrostructural regional brain development in preterm newborns.
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Commentary on “The long-term effect of perinatal asphyxia on hippocampal volumes”
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Brain abnormalities in children and adolescents with chronic kidney disease
Chronic kidney disease (CKD) is a risk factor for vascular disease and stroke. The spectrum of brain injury and microstructural white matter abnormalities in children with CKD is largely unknown.
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Neonatal stroke and haematuria: Questions
This is a report of an infant born near term with neonatal stroke and haematuria. Changes were noted on foetal magnetic resonance images, and these persisted postnatally. A routine renal ultrasound scan during...
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Neonatal stroke and haematuria: Answers
This is a report of an infant born near term with neonatal stroke and haematuria. The renal phenotype, pathogenic genotype and pathological findings on renal biopsy are discussed.
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Postnatal polyunsaturated fatty acids associated with larger preterm brain tissue volumes and better outcomes
Human studies investigating the link between postnatal polyunsaturated fatty acids and preterm brain growth are limited, despite emerging evidence of potential effects on outcomes.
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Early postnatal docosahexaenoic acid levels and improved preterm brain development
Preterm birth has a dramatic impact on polyunsaturated fatty acid exposures for the develo** brain. This study examined the association between postnatal fatty acid levels and measures of brain injury and de...
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Society for Pediatric Research 2014 Presidential Address: the test of our progress
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Resuscitation intensity at birth is associated with changes in brain metabolic development in preterm neonates
Intensive resuscitation at birth has been linked to intraventricular haemorrhage (IVH) in the preterm neonate. However, the impact of less intensive resuscitation on more subtle alterations in brain metabolic ...
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Visual function in preterm infants: visualizing the brain to improve prognosis
Considerable development of the visual system occurs in the third trimester of life, a time when very preterm-born infants are in a neonatal intensive care unit (NICU). Their very early birth during a period o...
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Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic–ischemic encephalopathy
Brain injury in term neonatal hypoxic–ischemic encephalopathy (HIE) emerges on magnetic resonance imaging (MRI) by day 3. This study aimed to address the relationship of MRI, diffusion tensor imaging (DTI), an...