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6 Result(s)

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  1. Article

    Open Access

    Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models

    Ca2+ entry via Ca2+ release-activated Ca2+ (CRAC) channels is a predominant mechanism of intracellular Ca2+ elevation in immune cells. Here we show the immunoregulatory role of CRAC channel components Orai1 and O...

    Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou… in Nature Communications (2023)

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  2. Article

    Open Access

    The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1

    Ca2+ release-activated Ca2+ (CRAC) channels elevate cytoplasmic Ca2+ concentration, which is essential for T cell activation, differentiation and effector functions. T cell receptor stimulation induces depletion ...

    ** Seok Woo, Zuoming Sun, Sonal Srikanth, Yousang Gwack in Scientific Reports (2020)

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  3. Article

    Open Access

    Dental enamel cells express functional SOCE channels

    Dental enamel formation requires large quantities of Ca2+ yet the mechanisms mediating Ca2+ dynamics in enamel cells are unclear. Store-operated Ca2+ entry (SOCE) channels are important Ca2+ influx mechanisms in ...

    Meerim K. Nurbaeva, Miriam Eckstein, Axel R. Concepcion… in Scientific Reports (2015)

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  4. No Access

    Article

    Orai1 is an essential pore subunit of the CRAC channel

    Two groups report the molecular identification of the long-sought CRAC channel as a plasma membrane protein known variously as olf186-F, Orai and CRACM1. The CRAC channel is of fundamental importance to Ca2+ sign...

    Murali Prakriya, Stefan Feske, Yousang Gwack, Sonal Srikanth, Anjana Rao… in Nature (2006)

  5. No Access

    Article

    A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

    Down's syndrome is caused by an extra chromosome; somehow a 1.5-fold increase in the dosage of a gene or genes on chromosome 21 causes the wide-reaching effects associated with the condition. A study using ‘kn...

    Yousang Gwack, Sonia Sharma, Julie Nardone, Bogdan Tanasa, Alina Iuga… in Nature (2006)

  6. No Access

    Article

    A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

    Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels, promoting the immune response to pathogens by activating the transcription factor NFAT. We have previou...

    Stefan Feske, Yousang Gwack, Murali Prakriya, Sonal Srikanth, Sven-Holger Puppel… in Nature (2006)