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Article
A molecular switch for neuroprotective astrocyte reactivity
The intrinsic mechanisms that regulate neurotoxic versus neuroprotective astrocyte phenotypes and their effects on central nervous system degeneration and repair remain poorly understood. Here we show that inj...
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Article
Shape of promoter antisense RNAs regulates ligand-induced transcription activation
The size of the transcriptional program of long non-coding RNAs in the mammalian genome has engendered discussions about their biological roles1, particularly the promoter antisense (PAS) transcripts2,3. Here we ...
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Article
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs
A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and is also observed for the truncated androgen recep...
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Article
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, eRNA transcription is shown to be functionally important during the activation of ...
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Article
DICER- and AGO3-dependent generation of retinoic acid–induced DR2 Alu RNAs regulates human stem cell proliferation
The biological importance of large numbers of retrotransposon-derived Alu repeats present in the human genome has been mysterious. New research reveals that many Alu repeats are bound and induced by retinoic a...
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Article
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
A non-coding region on chromosome 9p21 was previously shown to associate with coronary artery disease and type 2 diabetes, and the region has been implicated in regulating neighbouring genes. Here the authors ...
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Article
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
Mutations in the PHF8 gene, which encodes the plant homeo domain (PHD) finger protein 8, are connected to X-linked mental retardation associated with cleft lip and cleft palate. Two groups now report that the PHF...
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Article
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Down's syndrome is caused by an extra chromosome; somehow a 1.5-fold increase in the dosage of a gene or genes on chromosome 21 causes the wide-reaching effects associated with the condition. A study using ‘kn...
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Article
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels, promoting the immune response to pathogens by activating the transcription factor NFAT. We have previou...
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Chapter and Conference Paper
Client–Server P Systems in Modeling Molecular Interaction
We present a new version of P systems called Client-Server P Systems (CSPS). The client membranes are characterized by their states; the server membrane stores the states of the clients andtriggers ...
