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Article
Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells
The ZAP70 protein tyrosine kinase (PTK) couples stimulated T cell antigen receptors (TCRs) to their downstream signal transduction pathways and is sine qua non for T cell activation and differentiation. TCR engag...
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Article
Open AccessThe short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1
Ca2+ release-activated Ca2+ (CRAC) channels elevate cytoplasmic Ca2+ concentration, which is essential for T cell activation, differentiation and effector functions. T cell receptor stimulation induces depletion ...
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Article
Open AccessSumoylation of RORγt regulates TH17 differentiation and thymocyte development
RORγt controls the differentiation of TH17 cells, which are mediators of autoimmune conditions such as experimental autoimmune encephalomyelitis (EAE). RORγt also regulates thymocyte development and lymph node ge...
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Chapter and Conference Paper
Analysis on Causes of Flaring Cracks in Thin-Walled 5A02 Aluminum Alloy Tubes
In flaring process of some thin-walled 5A02 aluminum alloy tubes (“the tubes”) upon cold rolling and annealing, longitudinal cracks occur at the flared ends. In order to figure out the reason for these flaring...
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Article
A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development
Targeting the transcription factor RORγt in autoimmunity could disrupt thymocyte development and lead to thymic lymphoma. Sun and colleagues identify a two-amino-acid substitution in RORγt that ‘preferentially...
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Article
Open AccessPKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3+ Tregs, but not Foxp3− effector T-cells (Teff), when CD4+ T-cells are co-cultured with GM-CSF ...
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Article
Open AccessSoluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling
Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches...
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Chapter
Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes
Engagement of T cell receptors (TCRs) with cognate antigens triggers cascades of signaling pathways in helper T cells. TCR signaling is essential for the effector function of helper T cells including prolifera...
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Article
Analysis of shupe effect in polarization-maintaining photonic crystal fiber-optic gyroscope
The Shupe effect in a fiber optical gyroscope with polarization-maintaining photonic crystal fiber was studied. The thermal sensitivitise of the polarization-maintaining photonic crystal fiber and conventional...
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Reference Work Entry In depth
PKC-θ
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Article
β-Catenin/TCF-1 Pathway in T Cell Development and Differentiation
T cells must undergo two critical differentiation processes before they become competent effectors that can mediate actual immune responses. Progenitor T cells undergo defined stages of differentiation in the ...
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Article
Noise analysis of solid-core polarization-maintaining photonic interferometer fiber optic gyroscope
We report the prediction of the random walk coefficient of a solid-core single-mode polarization-maintaining photonic interferometer fiber optic gyroscope, a novel sensor that exhibits reduced thermal sensitiv...
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Article
Mechanisms regulating the development and function of natural regulatory T cells
The key of the immune system is to protect the host from foreign threat posed by pathogens and from the internal threat posed by self-attacking lymphocytes. The ability to discriminate self versus non-self ens...
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Article
Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes
T cell receptor (TCR) α alleles undergo primary and secondary rearrangement in double-positive (DP) thymocytes. By analyzing TCRα rearrangement in orphan nuclear receptor RORγ-deficient mice, in which the DP l...
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Article
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
Productive interaction of a T lymphocyte with an antigen-presenting cell results in the clustering of the T-cell antigen receptor (TCR) and the recruitment of a large signalling complex to the site of cell–cel...
