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Article
Open AccessLPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities
Activated fibroblasts are major mediators of pulmonary fibrosis. Fibroblasts are generally found in the connective tissue but upon activation can generate excess extracellular matrix (ECM) in the lung intersti...
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Article
Open AccessIs it what you say or how you say it?
This study investigates the mechanisms driving the effectiveness of free-form communication in promoting cooperation within a sequential social dilemma game. We hypothesize that the self-constructing nature of...
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Article
Open AccessCD248-expressing cancer-associated fibroblasts induce epithelial–mesenchymal transition of non-small cell lung cancer via inducing M2-polarized macrophages
Non-small cell lung cancer (NSCLC)-originating cancer-associated fibroblasts (CAFs) expressing CD248 regulate interaction with immune cells to accelerate cancer progression. Epithelial–mesenchymal transition (...
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Article
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
Breast cancer is the most commonly diagnosed cancer in women, and triple-negative breast cancer (TNBC) accounts for approximately 15%-20% of all breast cancers. TNBC is highly invasive and malignant. Due to th...
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Article
Open AccessDNA methylation patterns in patients with asthenospermia and oligoasthenospermia
Spermatogenesis is a highly regulated and complex process in which DNA methylation plays a crucial role. This study aimed to explore the differential methylation profiles in sperm DNA between patients with ast...
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Article
Association between cardiometabolic index and hepatic steatosis and liver fibrosis: a population-based study
The cardiometabolic index (CMI) is a new type of obesity index that is based on a combination of lipid levels and abdominal obesity indicators. It is closely correlated with the occurrence of diabetes mellitus...
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Article
Investigation of New Integrated Drought Monitoring Model Taking into Account the Effects of Climate Anomalies
Drought mechanisms vary markedly within different ecogeographical regions. Existing drought indices do not reflect the impact of climate anomalies on drought. In this study, the climate anomaly index was incor...
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Article
An intelligent DNA nanodevice for precision thrombolysis
Thrombosis is a leading global cause of death, in part due to the low efficacy of thrombolytic therapy. Here, we describe a method for precise delivery and accurate dosing of tissue plasminogen activator (tPA)...
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Article
Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer
Tumor immunotherapy brings new light and vitality to breast cancer patients, but low response rate and limitations of therapeutic targets become major obstacles to its clinical application. Recent studies have...
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Article
Supporting factors model for the sustainable step development of supply chain: An empirical study from China with grounded theory
The ongoing stability of supply chains faces significant challenges from trade protectionism, anti-globalization trends, and the COVID-19 pandemic. To remain resilient in this dynamic market environment, suppl...
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Article
Open AccessHBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored. H...
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Article
The Essential Role of PGF2α/PTGFR in Molding Endometrial Breakdown and Vascular Dynamics, Regulated by HIF-1α in a Mouse Menstrual-like Model
In women of childbearing age, extensive decidualization, shedding and remodeling of the endometrium during the menstrual cycle are fundamental for successful pregnancy. The role of prostaglandins (PGs) in mens...
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Article
The prevalence of oral frailty among older adults: a systematic review and meta‑analysis
This study is the first to explore the prevalence of oral frailty among older adults through systematic review and meta‑analysis.
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Article
An Efficient Probe-Based Quantitative PCR Assay Targeting Human-Specific DNA in ST6GALNAC3 for the Quantification of Human Cells in Preclinical Animal Models
Precise quantification of human cells in preclinical animal models by a sensitive and specific approach is warranted. The probe-based quantitative PCR (qPCR) assay as a sensitive and swift approach is suitable...
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Article
The PpMYB75-PpDFR module reveals the difference between ‘SR’ and its bud variant ‘RMHC’ in peach red flesh
‘Red Meat Honey Crisp (RMHC)’ has been widely cultivated by growers in recent years due to its early maturity, and red meat type characteristics. As a bud variant of ‘Super Red (SR)’ peach, red flesh is the mo...
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Article
The path from overqualification to success: career adaptability perspective
Perceived overqualification (POQ) has become a common experience across different workplaces. However, the present research has overlooked the circumstances in which overqualification can lead to favorable res...
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Article
Diagnostic performance of MRI for residual or recurrent hepatocellular carcinoma after locoregional treatment according to contrast agent type: a systematic review and meta‑analysis
The ideal contrast agent for imaging patients with hepatocellular carcinoma (HCC) following locoregional therapies (LRT) remains uncertain. We conducted a meta-analysis to assess the diagnostic performance of ...
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Article
Open AccessLNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing
Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic agents due to their ability to promote tissue regeneration. However, their limited tissue repair capability has posed a ...
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Article
Open AccessClinical efficacy of percutaneous endoscopic posterior lumbar interbody fusion and modified posterior lumbar interbody fusion in the treatment of lumbar degenerative disease
To compare the early clinical efficacy of percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF) and modified posterior lumbar interbody fusion (MPLIF) in the treatment of lumbar degenerative dise...
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Article
Open AccessIntra-ovarian inflammatory states and their associations with embryo quality in normal-BMI PCOS patients undergoing IVF treatment
Polycystic ovary syndrome (PCOS) is the main cause of anovulatory infertility in women of reproductive age, and low-grade chronic inflammation plays a key role in the occurrence and development of PCOS. Howeve...
