-
Article
Regioselective surface esterification of softwood mechanical pulp fines as hydrophilic paper strength additives
The fines fraction in mechanical pulp, produced during wood processing can impact the mechanical properties of the resulting paper positively or negatively, making them potential additives for paper strength i...
-
Article
Open AccessDeep learning-based multimodal analysis for transition-metal dichalcogenides
In this study, we present a novel approach to enable high-throughput characterization of transition-metal dichalcogenides (TMDs) across various layers, including mono-, bi-, tri-, four, and multilayers, utiliz...
-
Article
Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
-
Article
Open AccessRelationship between serum apolipoprotein B and risk of all-cause and cardiovascular disease mortality in individuals with hypertension: a prospective cohort study
Dyslipidemia frequently coexists with hypertension in the population. Apolipoprotein B (ApoB) is increasingly considered a more potent predictor of cardiovascular disease (CVD). Abnormal levels of serum ApoB c...
-
Article
Open Access2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumu...
-
Article
Open AccessSpecific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice
Exercise has beneficial effects on cognition throughout the lifespan. Here, we demonstrate that specific exercise patterns transform insufficient, subthreshold training into long-term memory in mice. Our findi...
-
Article
Quantile regression-enriched event modeling framework for dropout analysis in high-temperature superconductor manufacturing
High-temperature superconductor (HTS) tapes have shown promising characteristics of high critical current, which are prerequisites for applications in high-field magnets. Due to the unstable growth conditions ...
-
Article
Identification of Novel -Glucosidase Inhibitors from Syzygium jambos (L.) Using Spectroscopy and Molecular Docking
Fruits of Syzygium jambos (L.) are recognized as a “food”, exhibiting significant antidiabetic activities. However, the α-glucosidase inhibition of the components from Syzygium jambos (L.) have not yet been inves...
-
Article
Open AccessIncreased susceptibility to new-onset atrial fibrillation in diabetic women with poor sleep behaviour traits: findings from the prospective cohort study in the UK Biobank
Diabetic individuals often encounter various sleep-related challenges. Although the association between sleep duration and atrial fibrillation (AF) have been explored, the association of other sleep traits wit...
-
Article
Open AccessSuperior predictive value of estimated pulse wave velocity for all-cause and cardiovascular disease mortality risk in U.S. general adults
Estimated pulse wave velocity (ePWV) has been proposed as a potential approach to estimate carotid-femoral pulse wave velocity. However, the potential of ePWV in predicting all-cause mortality (ACM) and cardio...
-
Article
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
-
Article
A genomic mutational constraint map using variation in 76,156 human genomes
The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders1–4, but attempts to assess constraint f...
-
Article
Open AccessImpact of capitation prepayment on the medical expenses and health service utilization of patients with coronary heart disease: a community policy intervention program in a county in China
Medical costs have been rising rapidly in recent years, and China is controlling medical costs from the perspective of health insurance payments.
-
Article
Open AccessLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...
-
Article
Reinforcement learning for real-time process control in high-temperature superconductor manufacturing
With high efficiency and low energy loss, high-temperature superconductors (HTS) have demonstrated their profound applications in various fields, such as medical imaging, transportation, accelerators, microwav...
-
Article
A systematical review on ethnobotanical, phytochemical and pharmacological aspects of Dendrobium nobile Lindl.
Dendrobium nobile Lindl (DNL) is one of the main sources of traditional Chinese medicine, Shihu (Dendrobii caulis). In recent years, the strong antitumor activity of the extract from DNL makes it a hot research o...
-
Article
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis
Strains of the fungal genus Pestalotiopsis are reported as large promising sources of structurally varied biologically active metabolites. Many bioactive secondary metabolites with diverse structural features hav...
-
Article
Open AccessImpacting factors and sources of perceived stress by home-quarantined residents in Shanghai during COVID-19 epidemic
Home-quarantine is one of the most common measures implemented to prevent or minimize the transmission of COVID-19 among communities. This study assessed stress levels of the home-quarantined residents in Shan...
-
Article
Open AccessCell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency
Mutations in the solute carrier family 6-member 8 (Slc6a8) gene, encoding the protein responsible for cellular creatine (Cr) uptake, cause Creatine Transporter Deficiency (CTD), an X-linked neurometabolic disorde...
-
Article
Brain histone beta-hydroxybutyrylation couples metabolism with gene expression
Little is known about the impact of metabolic stimuli on brain tissue at a molecular level. The ketone body beta-hydroxybutyrate (BHB) can be a signaling molecule regulating gene transcription. Thus, we assess...
