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  1. Article

    Open Access

    Characterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer

    Tumor heterogeneity may broadly influence the activation of tumor-associated macrophages. We aimed to dissect how breast cancer cells of different molecular characteristics contribute to macrophage phenotype a...

    Maija Hollmén, Filip Roudnicky, Sinem Karaman, Michael Detmar in Scientific Reports (2015)

  2. Article

    Open Access

    Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice

    Obesity comprises great risks for human health, contributing to the development of other diseases such as metabolic syndrome, type 2 diabetes and cardiovascular disease. Previously, obese patients were found t...

    Sinem Karaman, Maija Hollmén, Sun-Young Yoon, H. Furkan Alkan in Scientific Reports (2016)

  3. Article

    Open Access

    3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

    Tryptophan catabolism is a major metabolic pathway utilized by several professional and non-professional antigen presenting cells to maintain immunological tolerance. Here we report that 3-hydroxy-l-kynurenamine ...

    Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy in Nature Communications (2021)