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Article
Evasion of Cas9 toxicity to develop an efficient genome editing system and its application to increase ethanol yield in Fusarium venenatum TB01
The clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas9) system is a powerful genome editing tool that has been successfully established in some filamentous fungi d...
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Article
Open AccessFrom formic acid to single-cell protein: genome-scale revealing the metabolic network of Paracoccus communis MA5
With the increase in population growth and environmental pollution, the daily protein supply is facing great challenges. Single-cell protein (SCP) produced by microorganism fermentation is a good alternative f...
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Article
Generalized message passing detection of SCMA systems based on dynamic factor graph for better and flexible performance-complexity tradeoff
Multiuser detection based on the message passing algorithm (MPA) has been considered for sparse code multiple access (SCMA) systems. Recently, some complexity-reduced MPA detectors have been proposed, among wh...
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Article
Open AccessSize and temperature effects on dielectric breakdown of ferroelectric films
The paper introduces a model of dielectric breakdown strength. The model integrated thermal breakdown and defect models, representing the relationship between the electric field of ferroelectric films and dime...
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Article
Engineered materials for in vivo delivery of genome-editing machinery
Genome-editing technologies, such as CRISPR–Cas9, are promising for treating otherwise incurable genetic diseases. Great progress has been made for ex vivo genome editing; however, major bottlenecks exist in t...
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Article
Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets
The potential of clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR associated protein 9 (Cas9)-based therapeutic genome editing is hampered by difficulties in the control of the in vivo...
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Article
Open AccessMagnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions
The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial ...
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Article
Open AccessA Self-Limiting Electro-Ablation Technique for the Top-Down Synthesis of Large-Area Monolayer Flakes of 2D Materials
We report the discovery of an electrochemical process that converts two dimensional layered materials of arbitrary thicknesses into monolayers. The lateral dimensions of the monolayers obtained by the process ...
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Article
Open AccessCharge collection kinetics on ferroelectric polymer surface using charge gradient microscopy
A charge gradient microscopy (CGM) probe was used to collect surface screening charges on poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] thin films. These charges are naturally formed on unscreened ...
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Chapter and Conference Paper
Frequency-Domain Turbo Equalization with Iterative Impulsive Noise Mitigation for Single-Carrier Power-Line Communications
Power-line communication (PLC) has been recognized as a promising alternative communication technology due to the universal existence of power lines. However, signal transmitted through PLC channel suffers fro...
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Article
Nanomedicine: Tiny Particles and Machines Give Huge Gains
Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Na...
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Article
Dense PLZT films grown on nickel substrates by PVP-modified sol–gel method
We have successfully grown ferroelectric Pb0.92La0.08Zr0.52Ti0.48O3 (PLZT) films on base metal foils by chemical solution deposition using sol–gel solutions containing polyvinylpyrrolidone. Under zero-bias field,...
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Article
Open AccessEngineering imaging probes and molecular machines for nanomedicine
Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Du...
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Article
Molecularly imprinted polymers for selective extraction of synephrine from Aurantii Fructus Immaturus
In this work, molecularly imprinted solid-phase extraction (MISPE) has been used to selectively enrich, purify, or remove synephrine from Aurantii Fructus Immaturus. To this end, a molecularly imprinted polymer (...
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Article
Fabrication and characterization of ferroelectric PLZT film capacitors on metallic substrates
We have grown ferroelectric Pb0.92La0.08Zr0.52Ti0.48O3 (PLZT) films on Hastelloy C276 (HC) substrates by chemical solution deposition. Samples of 1.15-μm-thick PLZT films were prepared on HC with and without lant...
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Article
Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay
GW5638 is a novel tissue-selective estrogen receptor (ER) modulator. Structurally, it is a derivative of tamoxifen that is known for its inhibitory effects on angiogenesis in an ER-independent manner. Therefor...
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Article
Available Space and Extracellular Transport of Macromolecules: Effects of Pore Size and Connectedness
Molecular exclusion in tumor tissues is one of the limiting factors for drug delivery to tumor cells. It can be quantified by the available volume fraction of solutes (KAV). We found in a previous study that KAV ...
