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  1. No Access

    Article

    Engineered materials for in vivo delivery of genome-editing machinery

    Genome-editing technologies, such as CRISPR–Cas9, are promising for treating otherwise incurable genetic diseases. Great progress has been made for ex vivo genome editing; however, major bottlenecks exist in t...

    Sheng Tong, Buhle Moyo, Ciaran M. Lee, Kam Leong, Gang Bao in Nature Reviews Materials (2019)

  2. Article

    Open Access

    ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells

    Management of infection with hepatitis B virus (HBV) remains a global health problem. Persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is responsible for modest curative eff...

    Tristan Scott, Buhle Moyo, Samantha Nicholson, Mohube Betty Maepa… in Scientific Reports (2017)

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