512 Result(s)

Article

Modulation of dlPFC function and decision-making capacity by repetitive transcranial magnetic stimulation in methamphetamine use disorder

This study explores the impact of repetitive transcranial magnetic stimulation (rTMS) on decision-making capabilities in individuals with methamphetamine use disorder (MUD), alongside potential underlying psyc...

Qingming Liu, Huimin Cui, Jiali Li, Ying Shen, Lei Zhang… in Translational Psychiatry (2024)

Article

Long-term survivals of immune checkpoint inhibitors as neoadjuvant and adjuvant therapy in dMMR/MSI-H colorectal and gastric cancers

The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) and gastric cancers (GC) with deficiency of mismatch repair (d...

Zhenghang Wang, Siyuan Cheng, Yanhong Yao, Shengde Liu… in Cancer Immunology, Immunotherapy (2024)

Article

The use of transcutaneous electrical acupoint stimulation to reduce opioid consumption in patients undergoing off-pump CABG: a randomized controlled trial

High doses of long-acting opioids were used to facilitate off-pump coronary artery bypass grafting procedure, which may result in opioid-related adverse events after surgery. Transcutaneous electrical acupoint...

Hui Zhang, Lini Wang, Ziyu Zheng, Jiange Han, Lin Li, Wenlong Yao… in Perioperative Medicine (2024)

Article

Aggravating effect of abnormal low-density protein cholesterol level on coronary atherosclerotic plaque in type 2 diabetes mellitus patients assessed by coronary computed tomography angiography

The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav...

Yi-Ning Jiang, Yue Gao, Yu-Shan Zhang, Chen-Yan Min… in Cardiovascular Diabetology (2024)

Article

CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis

Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosino...

Min Zhang, Lixia **a, Wenbei Peng, Guogang **e, Fei Li… in npj Precision Oncology (2024)

Article

Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...

Yanni Wang, Chang Liu, Huan Chen, ** Jiao… in Signal Transduction and Targeted Therapy (2024)

Article

Radiographic evaluation of robot-assisted versus manual total hip arthroplasty: a multicenter randomized controlled trial

The effectiveness of robot-assisted surgery remains contentious due to the lack of high-quality randomized controlled trials (RCTs) to elevate the level of evidence. We aimed to evaluate the postoperative radi...

**anzuo Zhang, **anyue Shen, Rongwei Zhang… in Journal of Orthopaedics and Traumatology (2024)

Article

The advanced lung cancer inflammation index is associated with mortality in peritoneal dialysis patients

There is still a very high morbidity and mortality rate for patients undergoing peritoneal dialysis (PD). The advanced lung cancer inflammation index (ALI) has been demonstrated to be associated with the progn...

Zhouhao Ren, Jiaying Wu, Shaorui Wu, Mengwei Zhang, Shuijuan Shen in BMC Nephrology (2024)

Article

Novel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations

Despite the efficacy of absolute ethanol (EtOH), its radiolucency introduces several risks in interventional therapy for treating vascular malformations. This study aims to develop a novel radiopaque ethanol i...

Yu-Chen Shen, De-Ming Wang, **-Tao Yang, Zhen-Feng Wang… in Military Medical Research (2024)

Article

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic mutations and clonal expansion in normal tis...

Shaosen Zhang, **nyi **ao, Yonglin Yi… in Signal Transduction and Targeted Therapy (2024)

Article

The role of age and AMH on cumulative live birth rates over multiple frozen-thawed embryo transfer cycles: a study based on low prognosis patients of POSEIDON 3 and 4 groups

Among the POSEIDON criteria, group 3 and group 4 have an expected low prognosis. For those patients with inadequate ovary reserve, embryo accumulated from consecutive oocyte retrieval cycles for multiple froze...

Lan **a, **aowei Zhou, **aoling Wang, Shen Zhao… in Reproductive Biology and Endocrinology (2024)

Article

B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation

B3GNT7, a glycosyltransferase of significant importance that is highly expressed in intestinal epithelial cells, plays a pivotal role in intestinal physiological processes. This study elucidates novel insights...

Tian Wang, Han Sun, Minna Zhang, Peng Shen, Yan Li in BMC Gastroenterology (2024)

Article

AI-2 quorum sensing-induced galactose metabolism activation in Streptococcus suis enhances capsular polysaccharide-associated virulence

Bacteria utilize intercellular communication to orchestrate essential cellular processes, adapt to environmental changes, develop antibiotic tolerance, and enhance virulence. This communication, known as quoru...

Shuji Gao, Chenlong Mao, Shuo Yuan, Yingying Quan, Wenjie **… in Veterinary Research (2024)

Article

Tunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study

Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients with NRAS-mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tun...

Yuankai Shi, **aohong Han, Qian Zhao, YuLong Zheng… in Experimental Hematology & Oncology (2024)

Article

The role of triglyceride-glucose index in the differential diagnosis of atherosclerotic stroke and cardiogenic stroke

This study aims to investigate the role of the triglyceride glucose (TyG) index in differentiating cardiogenic stroke (CE) from large atherosclerotic stroke (LAA).

Mengqian Liu, **aoyun Yang, Yi Jiang, Wen Zhong, Yiwen Xu… in BMC Cardiovascular Disorders (2024)

Article

Left atrial volume index and interleukin-6 as predictors for postoperative atrial fibrillation

Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery. However, the predictive value of single indictor still remains controversial. This study aimed to assess the predictive ...

Hong Tao, **ao Shen, Lei Zou, Cui Zhang, Liang Hong in Journal of Cardiothoracic Surgery (2024)

Article

Longitudinal dynamic single-cell mass cytometry analysis of peripheral blood mononuclear cells in COVID-19 patients within 6 months after viral RNA clearance

This study investigates the longitudinal dynamic changes in immune cells in COVID-19 patients over an extended period after recovery, as well as the interplay between immune cells and antibodies. Leveraging si...

Diwenxin Zhou, Shuai Zhao, Keting He, Qiuhong Liu, Fen Zhang… in BMC Infectious Diseases (2024)

Article

USP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer

This study investigates the role of USP47, a deubiquitinating enzyme, in the tumor microenvironment and its impact on antitumor immune responses. Analysis of TCGA database revealed distinct expression patterns...

Qian-Lan Wang, Shun-Yuan Lu, Dan-Dan Xu, **-**a Ma… in Cancer Immunology, Immunotherapy (2024)

Article

Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations

Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mut...

Meiying Shen, Siyin Chen, **aojian Han, Yanan Hao… in Cancer Immunology, Immunotherapy (2024)

Article

Correction: Characteristics and evaluation of C1 posterior arch variation for transpedicular screw placement between patients with and without basilar invagination

Lu-** Zhou, Chen-Hao Zhao, Zhi-Gang Zhang, ** Shang… in European Spine Journal (2024)