58 Result(s)

Article

Response to comment on “Effectiveness and safety of stem cell therapy for diabetic foot: a meta-analysis update”

Yuming Sun, **hong Zhao, Lifang Zhang, Zhexuan Li… in Stem Cell Research & Therapy (2024)

Article

Transplantation of the LRP1^high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice

Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demons...

Jiacheng Shen, Li Wu, **aoying Shi, Gang Chen, Tingwei Liu… in Stem Cell Research & Therapy (2024)

Article

Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naïve pluripotency transition process

Naïve pluripotent state can be obtained by several strategies from various types of cells, in which the cell fate roadmap as well as key biological events involved in the journey have been described in detail....

Zhifen Tu, Yan Bi, Tengyan Mao, Hong Wang, Shaorong Gao, Yixuan Wang in Cell Regeneration (2023)

Article

WD repeat domain 82 (Wdr82) facilitates mouse iPSCs generation by interfering mitochondrial oxidative phosphorylation and glycolysis

Abundantly expressed factors in the oocyte cytoplasm can remarkably reprogram terminally differentiated germ cells or somatic cells into totipotent state within a short time. However, the mechanism of the diff...

Guina Cui, **gxuan Zhou, Jiatong Sun, **aochen Kou… in Cellular and Molecular Life Sciences (2023)

Article

Resetting histone modifications during human prenatal germline development

Histone modifications play critical roles in regulating gene expression and present dynamic changes during early embryo development. However, how they are reprogrammed during human prenatal germline developmen...

Rui Gao, Shiyang Zeng, Dongxu Yang, **aocui Li, Wenqiang Liu, Yawei Gao… in Cell Discovery (2023)

Article

Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos

Metabolism feeds into the regulation of epigenetics via metabolic enzymes and metabolites. However, metabolic features, and their impact on epigenetic remodeling during mammalian pre-implantation development, ...

**gyu Li, Jiaming Zhang, Weibo Hou, Xu Yang, **aoyu Liu, Yan Zhang… in Cell Discovery (2022)

Article

Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation

Chromatin remodeling is essential for epigenome reprogramming after fertilization. However, the underlying mechanisms of chromatin remodeling remain to be explored. Here, we investigated the dynamic changes in...

Chenfei Wang, Chuan Chen, **aoyu Liu, Chong Li, Qiu Wu, **aolan Chen… in Cell Research (2022)

Article

Effectiveness and safety of stem cell therapy for diabetic foot: a meta-analysis update

Diabetic foot (DF) is one of the most common and serious complications of diabetes mellitus (DM), which brings great psychological and economic pressure to patients. This study aimed to evaluate the efficacy o...

Yuming Sun, **hong Zhao, Lifang Zhang, Zhexuan Li… in Stem Cell Research & Therapy (2022)

Article

BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding

Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3β and MEK inhibitors (2i) help to promote ground-state pluri...

Mingzhu Wang, Kun Zhao, Meng Liu, Mengting Wang, Zhibin Qiao, Shanru Yi… in Protein & Cell (2022)

Article

Correction to: Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

The original article can be found online at https://doi.org/10.1007/s13238-021-00837-8.

Chuan Chen, Wenqiang Liu, Jiayin Guo, Yuanyuan Liu, Xuelian Liu, Jun Liu… in Protein & Cell (2022)

Article

Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire

B1 cells are self-renewing innate-like B lymphocytes that provide the first line of defense against pathogens. B1 cells primarily reside in the peritoneal cavity and are known to originate from various fetal t...

Yao Luo, **g Wang, Kairui Li, Mingxia Li, Shasha Xu, **ngjie Liu… in Cell & Bioscience (2022)

Article

Nuclear m⁶A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

N⁶-methyladenosine (m⁶A) on chromosome-associated regulatory RNAs (carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and transcription, but the intrinsic mechanism remains uncle...

Chuan Chen, Wenqiang Liu, Jiayin Guo, Yuanyuan Liu, Xuelian Liu, Jun Liu… in Protein & Cell (2021)

Article

Insights into epigenetic patterns in mammalian early embryos

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to the formation of a totipotent embryo. During the development of the pre-implantatio...

Ruimin Xu, Chong Li, **aoyu Liu, Shaorong Gao in Protein & Cell (2021)

Article

A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos

During mammalian early embryogenesis, expression and epigenetic heterogeneity emerge before the first cell fate determination, but the programs causing such determinate heterogeneity are largely unexplored.

Chengchen Zhao, Naiqian Zhang, Yalin Zhang, Nuermaimaiti Tuersunjiang… in Genome Biology (2020)