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Article
Open AccessPig blastocyst-like structure models from embryonic stem cells
Pluripotent stem cells have the potential to generate embryo models that can recapitulate developmental processes in vitro. Large animals such as pigs may also benefit from stem-cell-based embryo models for im...
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Article
Open AccessExclusion of HDAC1/2 complexes by oncogenic nuclear condensates
Nuclear condensates have been shown to regulate cell fate control, but its role in oncogenic transformation remains largely unknown. Here we show acquisition of oncogenic potential by nuclear condensate remode...
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Article
Open AccessThe NuRD complex cooperates with SALL4 to orchestrate reprogramming
Cell fate decision involves rewiring of the genome, but remains poorly understood at the chromatin level. Here, we report that chromatin remodeling complex NuRD participates in closing open chromatin in the ea...
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Article
Open AccessGLEANER: a web server for GermLine cycle Expression ANalysis and Epigenetic Roadmap visualization
Germline cells are important carriers of genetic and epigenetic information transmitted across generations in mammals. During the mammalian germline cell development cycle (i.e., the germline cycle), cell pote...
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Article
Open AccessA DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos
During mammalian early embryogenesis, expression and epigenetic heterogeneity emerge before the first cell fate determination, but the programs causing such determinate heterogeneity are largely unexplored.
