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Article
Open AccessMetabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
N-Hydroxyapiosporamide (N-hydap), a marine product derived from a sponge-associated fungus, has shown promising inhibitory effects on small cell lung cancer (SCLC). However, there is limited understanding of its ...
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Article
Green roofs and their effect on architectural design and urban ecology using deep learning approaches
In recent years, the rapid development of the world’s economy has led to the large-scale development and utilization of ecological resources on the earth, due to which the ecological environment has been conti...
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Article
Mussel-inspired magnetic adsorbent MnO2/PDA@Fe3O4 for removing heavy metal ions contaminants in single and mixed systems
Heavy metal pollution has been a magnificent concern for a long period. A novel magnetic material, MnO2/PDA@Fe3O4, was prepared in this paper. With the assistance of multiple characterization methods, it was conf...
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Article
Open AccessCorrection to: Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
The original article can be found online at https://doi.org/10.1007/s13238-021-00837-8.
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Article
Open AccessDdCBE-mediated mitochondrial base editing in human 3PN embryos
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Article
Open AccessPrecision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing
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Article
Open AccessPrecision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing
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Article
Open AccessNuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
N6-methyladenosine (m6A) on chromosome-associated regulatory RNAs (carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and transcription, but the intrinsic mechanism remains uncle...
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Chapter and Conference Paper
Electric Vehicles and Renewable Energy Based on Coordinated and Optimal Dispatch
With the increasingly prominent energy and environmental issues, relevant experts and scholars began to focus on renewable energy. Based on the construction of the boundary conditions of electric vehicle charg...
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Article
Open AccessMetabolomic alternations of follicular fluid of obese women undergoing in-vitro fertilization treatment
Obesity exerts negative effects on the metabolic homeostasis of cells in various tissues, but how it influences ovum metabolism is not fully understood. Previous studies demonstrate that oocyte genes that regu...
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Article
Open Accessm6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Dynamic mRNA modification in the form of N6-methyladenosine (m6A) adds considerable richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed along mature mRNAs, with approximatel...
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Article
Open AccessNovel high-coverage targeted metabolomics method (SWATHtoMRM) for exploring follicular fluid metabolome alterations in women with recurrent spontaneous abortion undergoing in vitro fertilization
The complexity of follicular fluid metabolome presents a significant challenge for qualitative and quantitative metabolite profiling, and for discovering the comprehensive biomarkers. In order to address this ...
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Article
Open AccessMeclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification
N6-Methyladenosine (m6A), the most prevalent modification in mammalian mRNA, plays important roles in numerous biological processes. Several m6A associated proteins such as methyltransferase like 3 (METTL3), meth...
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Article
Open AccessIdentification of potential metabolic biomarkers of polycystic ovary syndrome in follicular fluid by SWATH mass spectrometry
Polycystic ovary syndrome (PCOS) is a complex disorder associated with multiple metabolic disturbance, including defective glucose metabolism and insulin resistance. The altered metabolites caused by the relat...
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Article
Open AccessCirculation of HAdV-41 with diverse genome types and recombination in acute gastroenteritis among children in Shanghai
Human adenovirus F (HAdV-F) is one of the major causative species detected in acute gastroenteritis in children worldwide. HAdV-F is composed of serotypes 40 and 41. Most studies have reported the prevalence o...
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Article
Open AccessThe roles of microRNAs in regulation of mammalian spermatogenesis
Mammalian spermatogenesis contains three continuous and organized processes, by which spermatogonia undergo mitosis and differentiate to spermatocytes, follow on meiosis to form haploid spermatids and ultimate...
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Article
Determination of A Novel Selective B-RafV600E Inhibitor (LXK4) in Dog Plasma by HPLC–MS/MS and its Application in a Pharmacokinetic Study
A rapid and sensitive HPLC–MS/MS assay was established and validated to quantify LXK4, a novel potent B-RafV600E inhibitor in dog plasma. The samples prepared by liquid–liquid extraction using ethyl acetate were ...
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Article
Recombinant expression, purification, and antimicrobial activity of a novel hybrid antimicrobial peptide LFT33
With great therapeutic potential against antibiotic-resistant bacteria, viruses, and even parasites, antimicrobial peptides (AMPs) have received increased interest as pharmaceutical agents in recent years. It ...
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Article
Expression and Purification of an Antimicrobial Peptide, Bovine Lactoferricin Derivative LfcinB-W10 in Escherichia coli
Antimicrobial peptides (AMPs) are extremely attractive candidate for therapeutic agents due to their wide spectrum of antimicrobial activity and action mechanism different from antibiotics. In this study, a me...
