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Article
Kee** up with the fast-moving world of crisis management
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Article
Open AccessComparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction
The mammalian adipose tissue plays a central role in energy-balance control, whereas the avian visceral fat hardly expresses leptin, the key adipokine in mammals. Therefore, to assess the endocrine role of adi...
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Article
Open AccessCorrespondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that hav...
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Article
Open AccessSystems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite
A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinu...
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Article
Open AccessCoordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project
We describe the organization of a nascent international effort, the Functional Annotation of Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps of functional elements in the genomes of ...
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Article
Open AccessProteogenomic map** of Mycoplasma hyopneumoniae virulent strain 232
Mycoplasma hyopneumoniae causes respiratory disease in swine and contributes to the porcine respiratory disease complex, a major disease problem in the swine industry. The M. hyopneumoniae strain 232 genome is on...
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Article
Open AccessNuclear Factor kappa B is central to Marek’s Disease herpesvirus induced neoplastic transformation of CD30 expressing lymphocytes in-vivo
Marek’s Disease (MD) is a hyperproliferative, lymphomatous, neoplastic disease of chickens caused by the oncogenic Gallid herpesvirus type 2 (GaHV-2; MDV). Like several human lymphomas the neoplastic MD lymphoma ...
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Article
Open AccessTranscriptome profile of a bovine respiratory disease pathogen: Mannheimia haemolytica PHL213
Computational methods for structural gene annotation have propelled gene discovery but face certain drawbacks with regards to prokaryotic genome annotation. Identification of transcriptional start sites, demar...
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Article
Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes
The International Crocodilian Genomes Working Group (ICGWG) will sequence and assemble the American alligator (Alligator mississippiensis), saltwater crocodile (Crocodylus porosus) and Indian gharial (Gavialis ga...
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Article
Systemic response to Campylobacter jejuni infection by profiling gene transcription in the spleens of two genetic lines of chickens
Campylobacter jejuni (C. jejuni) is a leading cause of human bacterial enteritis worldwide with poultry products being a major source of C. jejuni contamination. The chicken is the natura...
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RNA-Seq-based transcriptional map of the bovine respiratory disease pathogen Histophilus somni 2336
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RNA-Seq-based transcriptional map of the bovine respiratory disease pathogen Histophilus somni 2336
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Open AccessThe Proteogenomic Map** Tool
High-throughput mass spectrometry (MS) proteomics data is increasingly being used to complement traditional structural genome annotation methods. To keep pace with the high speed of experimental data generatio...
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Open AccessAn atlas of bovine gene expression reveals novel distinctive tissue characteristics and evidence for improving genome annotation
A comprehensive transcriptome survey, or gene atlas, provides information essential for a complete understanding of the genomic biology of an organism. We present an atlas of RNA abundance for 92 adult, juveni...
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Open AccessGOModeler- A tool for hypothesis-testing of functional genomics datasets
Functional genomics technologies that measure genome expression at a global scale are accelerating biological knowledge discovery. Generating these high throughput datasets is relatively easy compared to the d...
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Open AccessComplete genome and comparative analysis of the chemolithoautotrophic bacterium Oligotropha carboxidovorans OM5
Oligotropha carboxidovorans OM5 T. (DSM 1227, ATCC 49405) is a chemolithoautotrophic bacterium capable of utilizing CO (carbon monoxide) and fixing CO2 (carbon dioxide). We previously published the draft genome o...
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Article
Open AccessIdentification of novel non-coding small RNAs from Streptococcus pneumoniae TIGR4 using high-resolution genome tiling arrays
The identification of non-coding transcripts in human, mouse, and Escherichia coli has revealed their widespread occurrence and functional importance in both eukaryotic and prokaryotic life. In prokaryotes, studi...
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Gene Model Detection Using Mass Spectrometry
The utility of a genome sequence in biological research depends entirely on the comprehensive description of all of its functional elements. Analysis of genome sequences is still predominantly gene-centric (i....
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Article
Open AccessGenotype-Dependent Tumor Regression in Marek’s Disease Mediated at the Level of Tumor Immunity
Marek’s disease (MD) of chickens is a unique natural model of Hodgkin’s and Non Hodgkin’s lymphomas in which the neoplastically-transformed cells over-express CD30 (CD30hi) antigen. All chicken genotypes can be i...
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Article
Open AccessFacilitating functional annotation of chicken microarray data
Modeling results from chicken microarray studies is challenging for researchers due to little functional annotation associated with these arrays. The Affymetrix GenChip chicken genome array, one of the biggest...