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  1. No Access

    Article

    Signalling input from divergent pathways subverts B cell transformation

    Malignant transformation of cells typically involves several genetic lesions, whose combined activity gives rise to cancer1. Here we analyse 1,148 patient-derived B-cell leukaemia (B-ALL) samples, and find that i...

    Lai N. Chan, Mark A. Murakami, Mark E. Robinson, Rebecca Caeser, Teresa Sadras… in Nature (2020)

  2. Article

    Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors

    In Fig. 3c of this Letter, the the effects of CRISPR–Cas9-mediated deletion of NR3C1, TXNIP and CNR2 in patient-derived B-lineage leukaemia cells were shown. For curves depicting NR3C1 (left graph), data s for TX...

    Lai N. Chan, Zhengshan Chen, Daniel Braas, Jae-Woong Lee, Gang **ao, Huimin Geng… in Nature (2018)

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  3. No Access

    Article

    Metabolic gatekeeper function of B-lymphoid transcription factors

    The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensit...

    Lai N. Chan, Zhengshan Chen, Daniel Braas, Jae-Woong Lee, Gang **ao, Huimin Geng… in Nature (2017)

  4. Article

    Correction: Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

    Nature 521, 357–361 (2015); doi:10.1038/nature14231 In Extended Data Fig. 3b of this Letter, 52 flow cytometry dot plots with double stainings for CD19 and ITIM-bearing receptors (PECAM1, LAIR1, CD300A and BTL...

    Zhengshan Chen, Seyedmehdi Shojaee, Maike Buchner, Huimin Geng, Jae Woong Lee… in Nature (2016)

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  5. No Access

    Article

    PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

    As opposed to its tumor suppressor role in other cancers, PTEN inhibition in pre-B ALL is therapeutically effective and triggers cell death.

    Seyedmehdi Shojaee, Lai N Chan, Maike Buchner, Valeria Cazzaniga… in Nature Medicine (2016)

  6. No Access

    Article

    Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

    This study shows that, despite malignant transformation, autoimmune checkpoints are still functional in B-cell leukaemia, with targeted activation of these checkpoints effectively killing patient-derived B-cel...

    Zhengshan Chen, Seyedmehdi Shojaee, Maike Buchner, Huimin Geng, Jae Woong Lee… in Nature (2015)

  7. No Access

    Article

    BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

    Targeted cancer therapies are often associated with drug resistance, a phenomenon that has been observed with tyrosine kinase inhibitors (TKIs), widely used to treat leukaemia driven by BCR–ABL1 mutations. Markus...

    Cihangir Duy, Christian Hurtz, Seyedmehdi Shojaee, Leandro Cerchietti… in Nature (2011)