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  1. Article

    Open Access

    Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

    Cellular heterogeneity is a major cause of treatment resistance in cancer. Despite recent advances in single-cell genomic and transcriptomic sequencing, it remains difficult to relate measured molecular profil...

    Humberto Contreras-Trujillo, Jiya Eerdeng, Samir Akre, Du Jiang… in Nature Communications (2021)

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  2. Article

    Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

    A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03388-4.

    Jaewoong Lee, Mark E. Robinson, Ning Ma, Dewan Artadji, Mohamed A. Ahmed… in Nature (2021)

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  3. Article

    IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

    Interferon-induced transmembrane protein 3 (IFITM3) has previously been identified as an endosomal protein that blocks viral infection1–3. Here we studied clinical cohorts of patients with B cell leukaemia and ly...

    Jaewoong Lee, Mark E. Robinson, Ning Ma, Dewan Artadji, Mohamed A. Ahmed… in Nature (2020)

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  4. No Access

    Article

    Signalling input from divergent pathways subverts B cell transformation

    Malignant transformation of cells typically involves several genetic lesions, whose combined activity gives rise to cancer1. Here we analyse 1,148 patient-derived B-cell leukaemia (B-ALL) samples, and find that i...

    Lai N. Chan, Mark A. Murakami, Mark E. Robinson, Rebecca Caeser, Teresa Sadras… in Nature (2020)

  5. Article

    Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors

    In Fig. 3c of this Letter, the the effects of CRISPR–Cas9-mediated deletion of NR3C1, TXNIP and CNR2 in patient-derived B-lineage leukaemia cells were shown. For curves depicting NR3C1 (left graph), data s for TX...

    Lai N. Chan, Zhengshan Chen, Daniel Braas, Jae-Woong Lee, Gang **ao, Huimin Geng… in Nature (2018)

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  6. No Access

    Reference Work Entry In depth

    Protein Farnesyltransferase

    Lai N. Chan, Fuyuhiko Tamanoi in Encyclopedia of Signaling Molecules (2018)

  7. No Access

    Article

    Metabolic gatekeeper function of B-lymphoid transcription factors

    The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensit...

    Lai N. Chan, Zhengshan Chen, Daniel Braas, Jae-Woong Lee, Gang **ao, Huimin Geng… in Nature (2017)

  8. No Access

    Article

    PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

    As opposed to its tumor suppressor role in other cancers, PTEN inhibition in pre-B ALL is therapeutically effective and triggers cell death.

    Seyedmehdi Shojaee, Lai N Chan, Maike Buchner, Valeria Cazzaniga… in Nature Medicine (2016)

  9. Article

    Open Access

    In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

    Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and ...

    Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon… in BMC Cancer (2013)

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  10. No Access

    Reference Work Entry In depth

    Protein Farnesyltransferase

    Lai N. Chan, Prof. Fuyuhiko Tamanoi in Encyclopedia of Signaling Molecules (2012)