11 Result(s)
within
Seong Soo A. An
Life Sciences
-
Article
Open AccessBeauty of the beast: anticholinergic tropane alkaloids in therapeutics
Tropane alkaloids (TAs) are among the most valued chemical compounds known since pre-historic times. Poisonous plants from Solanaceae family (Hyoscyamus niger, Datura, Atropa belladonna, Scopolia lurida, Mandrago...
-
Article
Importance of GWAS in finding un-targeted genetic association of sporadic Alzheimer’s disease
Patients with sporadic Alzheimer’s do not possess an identified causative variant and hold an estimated heritability of 92–100%. Majority of disease causing, or protective mutations were uncommon in a generic ...
-
Article
Decreased plasma α-synuclein in idiopathic Parkinson’s disease patients after adjusting hemolysis factor
Lewy bodies are pathological hallmarks for the diagnosis of Parkinson’s disease, where the core components are composed of aggregated forms of α-synuclein (α-syn). Although α-syn has been investigated as a pot...
-
Article
Additional diagnostic testing of the 2019 novel coronavirus (SARS-CoV-2)
Within the last two decades several members of the Coronaviridae family namely Severe Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) have demonstrated epidemic potential. In la...
-
Article
Current fluid biomarkers, animal models, and imaging tools for diagnosing chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that results from repetitive traumatic brain injury (TBI), whether mild or severe. Several popular sports that subject the head to impact ...
-
Article
Novel GRN mutations in Koreans with Alzheimer’s disease
Backgrounds Alzheimer’s disease (AD) and fronto-temporal dementia (FTD) are the two most common neurodegenerative diseases leading to early onset dementia (<65 years). Mutations in the amyloid precursor protein, ...
-
Article
Clinical genetic strategies for early onset neurodegenerative diseases
Methods for the genetic diagnosis of neurodegenerative disorders were reviewed, including their backgrounds and applications in the laboratory. Majority of disease-causing gene mutations were uncommon in the g...
-
Article
In silico modeling of pathogenic or possibly pathogenic point mutations in PSEN2
Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder that affects memory, thinking, and behavior. 3 genes found to be involved in early-onset AD encode amyloid precursor protein (APP), p...
-
Article
Erratum to: Gene panels and primers for next generation sequencing studies on neurodegenerative disorders
-
Article
Gene panels and primers for next generation sequencing studies on neurodegenerative disorders
Several types of neurodegenerative diseases were described, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), prion disease, and Parkinson’s disease (PD). ...
-
Article
Fibrinogen as a promising material for various biomedical applications
As demands for innovative drug carriers and transplantable organs increase, many researchers have developed diverse drug carriers and scaffolds using various materials. However, several candidate materials hav...
