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Article
Open AccessAlpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease
Alpha-synuclein (α-syn) is considered the main pathophysiological protein component of Lewy bodies in synucleinopathies. α-Syn is an intrinsically disordered protein (IDP), and several types of structural conf...
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Article
Open AccessBeauty of the beast: anticholinergic tropane alkaloids in therapeutics
Tropane alkaloids (TAs) are among the most valued chemical compounds known since pre-historic times. Poisonous plants from Solanaceae family (Hyoscyamus niger, Datura, Atropa belladonna, Scopolia lurida, Mandrago...
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Article
A Creutzfeldt–Jakob disease patient with V180I mutation survived for 16.5 years after diagnosis
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Article
Open AccessEnhanced proliferation of rabbit chondrocytes by using a well circulated nanoshock system
The gold nanorods (GNRs) embedded alginate-chitosan (scaffold), which was designed and fabricated to produce efficient handling of the cell proliferations. Scaffold embedded GNR (SGNR) and NIR (near infrared) ...
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Article
Open AccessPlasma amyloid-β oligomerization assay as a pre-screening test for amyloid status
We assessed the performance of plasma amyloid oligomerization tendency (OAβ) as a marker for abnormal amyloid status. Additionally, we examined long-term storage effects on plasma OAβ.
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Article
Importance of GWAS in finding un-targeted genetic association of sporadic Alzheimer’s disease
Patients with sporadic Alzheimer’s do not possess an identified causative variant and hold an estimated heritability of 92–100%. Majority of disease causing, or protective mutations were uncommon in a generic ...
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Article
Neuroprotective effects on amyloid-beta induced cytotoxicity of Pandanus clementis Merr
The present study determined the neuroprotective potential of the alcoholic and aqueous extracts of Pandanus clementis Merr. (Pandanaceae) to protect the neuroblastoma SH-SY5Y cells against amyloid-beta1-42 (Aβ) ...
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SARS-CoV-2 (COVID-19): Beginning to Understand a New Virus
Within the last two decades, several members of the Coronaviridae family demonstrated epidemic potential. In late 2019, an unnamed genetic relative, later named SARS-CoV-2 (COVID-19), erupted in the highly pop...
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Article
Neuroprotective potential of the oxindole alkaloids isomitraphylline and mitraphylline in human neuroblastoma SH-SY5Y cells
The purified oxindole alkaloids, isomitraphylline and mitraphylline from Uncaria perrottetii, revealed their ability to break amyloid aggregates in vitro suggesting their therapeutic potentials in Alzheimer’s dis...
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Article
Decreased plasma α-synuclein in idiopathic Parkinson’s disease patients after adjusting hemolysis factor
Lewy bodies are pathological hallmarks for the diagnosis of Parkinson’s disease, where the core components are composed of aggregated forms of α-synuclein (α-syn). Although α-syn has been investigated as a pot...
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Article
Additional diagnostic testing of the 2019 novel coronavirus (SARS-CoV-2)
Within the last two decades several members of the Coronaviridae family namely Severe Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) have demonstrated epidemic potential. In la...
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Article
Neuroprotective effects of vomifoliol, isolated from Tarenna obtusifolia Merr. (Rubiaceae), against amyloid-beta1-42-treated neuroblastoma SH-SY5Y cells
Phytochemical investigation on the leaves of Tarenna obtusifolia Merr. (Rubiaceae) led to the isolation and identification of vomifoliol (1), p-coumaric acid (2), and stigmasterol (3) based on spectroscopic analy...
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Article
Open AccessCSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation
Recently, several studies suggested potential involvements of α-synuclein in Alzheimer’s disease (AD) pathophysiology. Higher concentrations of α-synuclein were reported in cerebrospinal fluid (CSF) of AD pati...
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Article
Neuroblastoma SH-SY5Y cytotoxicity, anti-amyloidogenic activity and cyclooxygenase inhibition of Lasianthus trichophlebus (Rubiaceae)
The anti-amyloidogenic potential and cyclooxygenase anti-inflammatory activity of Lasianthus trichophlebus extracts were evaluated. The MeOH extract (LTM) and chloroform extract (LTC) exhibited significant cytoto...
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Article
In vivo COX-2 modulation and metabolite profiling of Pandanus tectorius leaves extracts
The Pandanus tectorius methanolic (PTM) and P. tectorius aqueous (PTA) extracts were investigated for their potential in vivo anti-inflammatory activity using carrageenan-induced rat paw edema. Parameters includi...
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Article
Open AccessAssociation between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease
The objectives of this study were to investigate whether the plasma levels of oligomeric amyloid-β (OAβ) were affected in Alzheimer’s disease (AD) and to examine the associations (or possible correlations) bet...
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Article
Current fluid biomarkers, animal models, and imaging tools for diagnosing chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that results from repetitive traumatic brain injury (TBI), whether mild or severe. Several popular sports that subject the head to impact ...
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Article
Open AccessA pathogenic PSEN1 Trp165Cys mutation associated with early-onset Alzheimer’s disease
Presenilin-1 (PSEN1) is one of the causative genes for early onset Alzheimer’s disease (EOAD). Recently, emerging studies reported several novel PSEN1 mutations among Asian. We describe a male with EOAD had a ...
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Article
Novel GRN mutations in Koreans with Alzheimer’s disease
Backgrounds Alzheimer’s disease (AD) and fronto-temporal dementia (FTD) are the two most common neurodegenerative diseases leading to early onset dementia (<65 years). Mutations in the amyloid precursor protein, ...
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Article
Open AccessGenetic analyses of early-onset Alzheimer’s disease using next generation sequencing
Alzheimer’s disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly understood. Many mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN1 ...
